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Descriptor English: Cardiac Glycosides
Descriptor Spanish: Glicósidos Cardíacos
Descriptor glicósidos cardíacos
Entry term(s) esteroide cardiotónico
esteroides cardiotónicos
glucósido cardíaco
glucósidos cardíacos
Scope note: Ciclopentanofenantrenos con un anillo de lactona de 5 o 6 miembros en la posición 17 y AZÚCARES unidos en la posición 3. Las plantas de las que proceden se han utilizado durante mucho tiempo en el tratamiento de la insuficiencia cardiaca congestiva. Aumentan la fuerza de la contracción cardíaca sin incrementar significativamente otros parámetros, pero son muy tóxicos en altas dosis. Su mecanismo de acción suele implicar la inhibición de la ATPASA INTERCAMBIADORA DE SODIO-POTASIO, y se utilizan a menudo en estudios de biología celular con ese propósito.
Descriptor Portuguese: Glicosídeos Cardíacos
Descriptor French: Glucosides cardiotoniques
Entry term(s): Cardiac Glycoside
Cardiotonic Steroid
Cardiotonic Steroids
Glycoside, Cardiac
Glycosides, Cardiac
Steroid, Cardiotonic
Steroids, Cardiotonic
Tree number(s): D04.210.500.155.580
D09.408.180
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D002301
Scope note: Cyclopentanophenanthrenes with a 5- or 6-membered lactone ring attached at the 17-position and SUGARS attached at the 3-position. Plants they come from have long been used in congestive heart failure. They increase the force of cardiac contraction without significantly affecting other parameters, but are very toxic at larger doses. Their mechanism of action usually involves inhibition of the NA(+)-K(+)-EXCHANGING ATPASE and they are often used in cell biological studies for that purpose.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Anti-Arrhythmia Agents
Cardiotonic Agents
Enzyme Inhibitors
DeCS ID: 2345
Unique ID: D002301
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1966/01/01
Date of Entry: 1999/01/01
Revision Date: 2020/05/27
Cardiac Glycosides - Preferred
Concept UI M0003451
Scope note Cyclopentanophenanthrenes with a 5- or 6-membered lactone ring attached at the 17-position and SUGARS attached at the 3-position. Plants they come from have long been used in congestive heart failure. They increase the force of cardiac contraction without significantly affecting other parameters, but are very toxic at larger doses. Their mechanism of action usually involves inhibition of the NA(+)-K(+)-EXCHANGING ATPASE and they are often used in cell biological studies for that purpose.
Preferred term Cardiac Glycosides
Entry term(s) Cardiac Glycoside
Cardiotonic Steroid
Cardiotonic Steroids
Glycoside, Cardiac
Glycosides, Cardiac
Steroid, Cardiotonic
Steroids, Cardiotonic



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