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Descriptor in English: Cardiac Glycosides
Descriptor in Spanish: Glicósidos Cardíacos
Descriptor in Portuguese: Glicosídeos Cardíacos
Descriptor in French: Glucosides cardiotoniques
Entry term(s): Cardiotonic Steroids
Glycosides, Cardiac
Steroids, Cardiotonic
Tree number(s): D04.210.500.155.580
D09.408.180
Scope note: Cyclopentanophenanthrenes with a 5- or 6-membered lactone ring attached at the 17-position and SUGARS attached at the 3-position. Plants they come from have long been used in congestive heart failure. They increase the force of cardiac contraction without significantly affecting other parameters, but are very toxic at larger doses. Their mechanism of action usually involves inhibition of the NA(+)-K(+)-EXCHANGING ATPASE and they are often used in cell biological studies for that purpose.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
DeCS UI: 2345
Descriptor UI: D002301
Date Established: 1966/01/01
Date of Entry: 1999/01/01
Revision Date: 2016/05/27
Cardiac Glycosides - Preferred
Concept UI M0003451
Scope note Cyclopentanophenanthrenes with a 5- or 6-membered lactone ring attached at the 17-position and SUGARS attached at the 3-position. Plants they come from have long been used in congestive heart failure. They increase the force of cardiac contraction without significantly affecting other parameters, but are very toxic at larger doses. Their mechanism of action usually involves inhibition of the NA(+)-K(+)-EXCHANGING ATPASE and they are often used in cell biological studies for that purpose.
Preferred term Cardiac Glycosides
Entry term(s) Cardiotonic Steroids
Glycosides, Cardiac
Steroids, Cardiotonic



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