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Descriptor English: Diphenoxylate
Descriptor Spanish: Difenoxilato
Descriptor difenoxilato
Scope note: Del mismo grupo que la MEPERIDINA, se utiliza como antidiarreico, generalmente en combinación con la ATROPINA. A dosis elevadas actúa como la morfina. Su metabolito no esterificado, la difenoxina, tiene propiedades similares y es utilizado de la misma manera.
Descriptor Portuguese: Difenoxilato
Descriptor French: Diphénoxylate
Entry term(s): Diphenoxylate Hydrochloride
Diphenoxylate Monohydrochloride
Hydrochloride, Diphenoxylate
Monohydrochloride, Diphenoxylate
Tree number(s): D03.066.399.300
D03.383.621.349.300
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D004157
Scope note: A MEPERIDINE congener used as an antidiarrheal, usually in combination with ATROPINE. At high doses, it acts like morphine. Its unesterified metabolite difenoxin has similar properties and is used similarly. It has little or no analgesic activity.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Analgesics, Opioid
Antidiarrheals
Registry Number: 73312P173G
CAS Type 1 Name: 4-Piperidinecarboxylic acid, 1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-, ethyl ester
Previous Indexing: Isonipecotic Acids (1970-1974)
Nitriles (1974)
Public MeSH Note: 91; was see under ISONIPECOTIC ACIDS 1975-90
History Note: 91(75); was see under ISONIPECOTIC ACIDS 1975-90
DeCS ID: 4212
Unique ID: D004157
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1974/11/11
Revision Date: 2016/05/31
Diphenoxylate - Preferred
Concept UI M0006512
Scope note A MEPERIDINE congener used as an antidiarrheal, usually in combination with ATROPINE. At high doses, it acts like morphine. Its unesterified metabolite difenoxin has similar properties and is used similarly. It has little or no analgesic activity.
Preferred term Diphenoxylate
Diphenoxylate Hydrochloride - Narrower
Concept UI M0006513
Preferred term Diphenoxylate Hydrochloride
Entry term(s) Diphenoxylate Monohydrochloride
Hydrochloride, Diphenoxylate
Monohydrochloride, Diphenoxylate



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