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Descriptor English: Glucagon-Like Peptide 1
Descriptor Spanish: Péptido 1 Similar al Glucagón
Descriptor péptido glucagonoide 1
Entry term(s) péptido 1 glucagonoide
péptido 1 similar al glucagón
péptido glucagonoide de tipo 1
péptido similar al glucagón 1
péptido similar al glucagón de tipo 1
Scope note: Péptido de 36 o 37 aminoácidos derivado del PROGLUCAGÓN y que es producido principalmente por las CÉLULAS L INTESTINALES. El GLP-1 (1-37 o 1-36) es truncada en el extremo N-terminal, dando lugar al GLP-1(7-37) o al GLP-1(7-36), que pueden aminarse. Estos péptidos GLP-1 son conocidos por aumentar la secreción de INSULINA dependiente de la glucosa, inhibir la secreción de GLUCAGÓN y el vaciamiento gástrico, reducir la GLUCEMIA y la ingesta de alimentos.
Descriptor Portuguese: Peptídeo 1 Semelhante ao Glucagon
Descriptor French: Glucagon-like peptide 1
Entry term(s): GLP 1
GLP-1
Glucagon Like Peptide 1
Glucagon-Like Peptide-1
Tree number(s): D06.472.317.680.500.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D052216
Scope note: A peptide of 36 or 37 amino acids that is derived from PROGLUCAGON and mainly produced by the INTESTINAL L CELLS. GLP-1(1-37 or 1-36) is further N-terminally truncated resulting in GLP-1(7-37) or GLP-1-(7-36) which can be amidated. These GLP-1 peptides are known to enhance glucose-dependent INSULIN release, suppress GLUCAGON release and gastric emptying, lower BLOOD GLUCOSE, and reduce food intake.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Incretins
Registry Number: 89750-14-1
Public MeSH Note: 2006
History Note: 2006
DeCS ID: 50567
Unique ID: D052216
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2006/01/01
Date of Entry: 2005/06/30
Revision Date: 2018/07/05
Glucagon-Like Peptide 1 - Preferred
Concept UI M0160181
Scope note A peptide of 36 or 37 amino acids that is derived from PROGLUCAGON and mainly produced by the INTESTINAL L CELLS. GLP-1(1-37 or 1-36) is further N-terminally truncated resulting in GLP-1(7-37) or GLP-1-(7-36) which can be amidated. These GLP-1 peptides are known to enhance glucose-dependent INSULIN release, suppress GLUCAGON release and gastric emptying, lower BLOOD GLUCOSE, and reduce food intake.
Preferred term Glucagon-Like Peptide 1
Entry term(s) GLP 1
GLP-1
Glucagon Like Peptide 1
Glucagon-Like Peptide-1



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