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Descriptor English: Methylmalonate-Semialdehyde Dehydrogenase (Acylating)
Descriptor Spanish: Metilmalonato-Semialdehído Deshidrogenasa (Acetilante)
Descriptor metilmalonato-semialdehído deshidrogenasa (acilante)
Entry term(s) metilmalonato-semialdehído dehidrogenasa (acetilante)
Scope note: Enzima que interviene en las vías del catabolismo de la VALINA, LEUCINA e ISOLEUCINA, catalizando la oxidación del 2-metil-3-oxopropanato a propanoil-CoA usando NAD+ como coenzima. La deficiencia de metilmalonato-semialdehído deshidrogenasa se caracteriza por elevación de la BETA-ALANINA y del ÁCIDO 3-HIDROXIPROPIÓNICO.
Descriptor Portuguese: Metilmalonato-Semialdeído Desidrogenase (Acilante)
Descriptor French: Methylmalonate-semialdehyde dehydrogenase (acylating)
Entry term(s): Dehydrogenase, MMSA
MMSA Dehydrogenase
MMSDH
Methylmalonic-Semialdehyde Dehydrogenase (Acylating)
Tree number(s): D08.811.682.657.163.827
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D050646
Scope note: An enzyme that plays a role in the VALINE; LEUCINE; and ISOLEUCINE catabolic pathways by catalyzing the oxidation of 2-methyl-3-oxopropanate to propanoyl-CoA using NAD+ as a coenzyme. Methylmalonate semialdehyde dehydrogenase deficiency is characterized by elevated BETA-ALANINE and 3-hydropropionic acid.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 1.2.1.27
Public MeSH Note: 2006; METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE (ACYLATING) was indexed under ALDEHYDE OXIDOREDUCTASES 1987-2005
History Note: 2006(1987)
DeCS ID: 50617
Unique ID: D050646
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2006/01/01
Date of Entry: 2005/06/30
Revision Date: 2009/07/15
Methylmalonate-Semialdehyde Dehydrogenase (Acylating) - Preferred
Concept UI M0144948
Scope note An enzyme that plays a role in the VALINE; LEUCINE; and ISOLEUCINE catabolic pathways by catalyzing the oxidation of 2-methyl-3-oxopropanate to propanoyl-CoA using NAD+ as a coenzyme. Methylmalonate semialdehyde dehydrogenase deficiency is characterized by elevated BETA-ALANINE and 3-hydropropionic acid.
Preferred term Methylmalonate-Semialdehyde Dehydrogenase (Acylating)
Entry term(s) Dehydrogenase, MMSA
MMSA Dehydrogenase
MMSDH
Methylmalonic-Semialdehyde Dehydrogenase (Acylating)



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