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Descriptor English: Succinate-Semialdehyde Dehydrogenase
Descriptor Spanish: Succionato-Semialdehído Deshidrogenasa
Descriptor succionato-semialdehído deshidrogenasa
Scope note: Enzima que interviene en el METABOLISMO del GLUTAMATO y del butanoato catalizando la oxidación del succinato-semialdehído a SUCCINATO usando NAD+ como coenzima. La deficiencia de esta enzima causa aciduria 4-hidroxibutírica, un error innato poco frecuente del metabolismo del neurotransmisor ácido 4-aminobutírico (GABA).
Descriptor Portuguese: Succinato-Semialdeído Desidrogenase
Descriptor French: Succinate-semialdehyde dehydrogenase
Entry term(s): Dehydrogenase, Succinate Semialdehyde
Dehydrogenase, Succinate-Semialdehyde
Dehydrogenase, Succinic Semialdehyde
NAD(+)-Dependent Succinic Semialdehyde Dehydrogenase
Semialdehyde Dehydrogenase, Succinate
Semialdehyde Dehydrogenase, Succinic
Succinate Semialdehyde Dehydrogenase
Succinic Semialdehyde Dehydrogenase
Tree number(s): D08.811.682.657.163.843
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D050644
Scope note: An enzyme that plays a role in the GLUTAMATE and butanoate metabolism pathways by catalyzing the oxidation of succinate semialdehyde to SUCCINATE using NAD+ as a coenzyme. Deficiency of this enzyme, causes 4-hydroxybutyricaciduria, a rare inborn error in the metabolism of the neurotransmitter 4-aminobutyric acid (GABA).
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 1.2.1.24
Public MeSH Note: 2006; SUCCINATE-SEMIALDEHYDE DEHYDROGENASE was indexed under ALDEHYDE OXIDOREDUCTASES 1977-2005
History Note: 2006(1980); use ALDEHYDE OXIDREDUCTASES 1977-1979
DeCS ID: 50619
Unique ID: D050644
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2006/01/01
Date of Entry: 2005/06/30
Succinate-Semialdehyde Dehydrogenase - Preferred
Concept UI M0079133
Scope note An enzyme that plays a role in the GLUTAMATE and butanoate metabolism pathways by catalyzing the oxidation of succinate semialdehyde to SUCCINATE using NAD+ as a coenzyme. Deficiency of this enzyme, causes 4-hydroxybutyricaciduria, a rare inborn error in the metabolism of the neurotransmitter 4-aminobutyric acid (GABA).
Preferred term Succinate-Semialdehyde Dehydrogenase
Entry term(s) Dehydrogenase, Succinate Semialdehyde
Dehydrogenase, Succinate-Semialdehyde
Dehydrogenase, Succinic Semialdehyde
NAD(+)-Dependent Succinic Semialdehyde Dehydrogenase
Semialdehyde Dehydrogenase, Succinate
Semialdehyde Dehydrogenase, Succinic
Succinate Semialdehyde Dehydrogenase
Succinic Semialdehyde Dehydrogenase



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