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Descriptor English: 2-Oxoisovalerate Dehydrogenase (Acylating)
Descriptor Spanish: 2-Oxoisovalerato Deshidrogenasa (Acilante)
Descriptor 2-oxoisovalerato deshidrogenasa (acilante)
Scope note: Enzima dependiente de NAD+ que cataliza la oxidación de 3-metil-2-oxobutanoato a 2-metilpropanoil-CoA. Interviene en la degradación de la VALINA, LEUCINA e ISOLEUCINA.
Descriptor Portuguese: 2-Oxoisovalerato Desidrogenase (Acilante)
Descriptor French: 2-Oxoisovalerate dehydrogenase (acylating)
Entry term(s): 2 Oxoisovalerate Dehydrogenase
2-Oxoisovalerate Dehydrogenase
Dehydrogenase, 2-Oxoisovalerate
Dehydrogenase, alpha-Ketoisovalerate
alpha Ketoisovalerate Dehydrogenase
alpha-Ketoisovalerate Dehydrogenase
Tree number(s): D08.811.682.657.350.825
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D050645
Scope note: An NAD+ dependent enzyme that catalyzes the oxidation 3-methyl-2-oxobutanoate to 2-methylpropanoyl-CoA. It plays a role in the degradation of VALINE; LEUCINE; and ISOLEUCINE.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 1.2.1.25
Public MeSH Note: 2006; 2-OXOISOVALERATE DEHYDROGENASE (ACYLATING) was indexed under KETONE OXIDOREDUCTASES 1983-2005, under AMINO ACIDS, BRANCHED-CHAIN 1979-1982, under KETO ACIDS 1973-1982, & VALERATES 1973-1979
History Note: 2006(1980); use AMINO ACIDS, BRANCHED-CHAIN 1979, & KETO ACIDS & VALERATES 1973-1979
DeCS ID: 50621
Unique ID: D050645
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2006/01/01
Date of Entry: 2005/06/30
2-Oxoisovalerate Dehydrogenase (Acylating) - Preferred
Concept UI M0077427
Scope note An NAD+ dependent enzyme that catalyzes the oxidation 3-methyl-2-oxobutanoate to 2-methylpropanoyl-CoA. It plays a role in the degradation of VALINE; LEUCINE; and ISOLEUCINE.
Preferred term 2-Oxoisovalerate Dehydrogenase (Acylating)
Entry term(s) 2 Oxoisovalerate Dehydrogenase
2-Oxoisovalerate Dehydrogenase
Dehydrogenase, 2-Oxoisovalerate
Dehydrogenase, alpha-Ketoisovalerate
alpha Ketoisovalerate Dehydrogenase
alpha-Ketoisovalerate Dehydrogenase



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