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Descriptor English: bcl-X Protein
Descriptor Spanish: Proteína bcl-X
Descriptor proteína bcl-X
Entry term(s) proteína bcl-XL
proteína bcl-XS
Scope note: Miembro de la familia de proteínas bcl-2 que desempeña un papel en la regulación de la APOPTOSIS y es una subunidad reguladora de la PROTEÍNA FOSFATASA 1. Hay dos isoformas principales de la proteína debido al EMPALME ALTERNATIVO del ARNm de BCL2L1, denominadas Bcl-XS y Bcl-XL.
Descriptor Portuguese: Proteína bcl-X
Descriptor French: Protéine bcl-X
Entry term(s): bcl X Protein
bcl XL Protein
bcl XS Protein
bcl Xa Protein
bcl Xalpha Protein
bcl Xb Protein
bcl Xbeta Protein
bcl Xlong Protein
bcl Xshort Protein
bcl-X(L) Protein
bcl-X(S) Protein
bcl-XL Protein
bcl-XS Protein
bcl-Xa Protein
bcl-Xalpha Protein
bcl-Xb Protein
bcl-Xbeta Protein
bcl-Xlong Protein
bcl-Xshort Protein
bcl-x(beta) Protein
bcl2 Like 1 Protein
bcl2-Like 1 Protein
bcl2L1 Protein
Tree number(s): D12.644.360.075.718.937
D12.776.476.075.718.875
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D051020
Scope note: A member of the bcl-2 protein family that plays a role in the regulation of APOPTOSIS and is a regulatory subunit for PROTEIN PHOSPHATASE 1. Two major isoforms of the protein exist due to ALTERNATIVE SPLICING of the BCL2L1 mRNA and are referred to as Bcl-XS and Bcl-XL.
Annotation: do not confuse with the closely related BCL2-ASSOCIATED X PROTEIN
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Public MeSH Note: 2006; BCL-X PROTEIN was indexed under PROTO-ONCOGENE PROTEINS 1993-2004, & under PROTO-ONCOGENE PROTEINS C-BCL-2 2005
History Note: 2006(1993)
DeCS ID: 50808
Unique ID: D051020
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2006/01/01
Date of Entry: 2005/06/30
Revision Date: 2015/12/01
bcl-X Protein - Preferred
Concept UI M0220648
Scope note A member of the bcl-2 protein family that plays a role in the regulation of APOPTOSIS and is a regulatory subunit for PROTEIN PHOSPHATASE 1. Two major isoforms of the protein exist due to ALTERNATIVE SPLICING of the BCL2L1 mRNA and are referred to as Bcl-XS and Bcl-XL.
Preferred term bcl-X Protein
Entry term(s) bcl X Protein
bcl2 Like 1 Protein
bcl2-Like 1 Protein
bcl2L1 Protein
bcl-XS Protein - Narrower
Concept UI M0220646
Scope note A pro-apoptotic protein that is the short isoform of Bcl-X protein. Bcl-XS lacks the BH1 and BH2 domains of BCL-XL PROTEIN and it inhibits the ANTI-APOPTOTIC PROTEINS of the bcl-2 protein family.
Preferred term bcl-XS Protein
Entry term(s) bcl XS Protein
bcl Xshort Protein
bcl-X(S) Protein
bcl-Xshort Protein
bcl-Xalpha Protein - Narrower
Concept UI M0478996
Preferred term bcl-Xalpha Protein
Entry term(s) bcl Xa Protein
bcl Xalpha Protein
bcl-Xa Protein
bcl-Xbeta Protein - Narrower
Concept UI M0480110
Preferred term bcl-Xbeta Protein
Entry term(s) bcl Xb Protein
bcl Xbeta Protein
bcl-Xb Protein
bcl-x(beta) Protein
bcl-XL Protein - Narrower
Concept UI M0220645
Scope note Bcl-XL is an anti-apoptotic protein that is the long isoform of Bcl-X protein. Bcl-XL localizes to the outer mitochondrial membrane and is overexpressed in most human NEOPLASMS. It has also been implicated in ISCHEMIC HEART DISEASE.
Preferred term bcl-XL Protein
Entry term(s) bcl XL Protein
bcl Xlong Protein
bcl-X(L) Protein
bcl-Xlong Protein



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