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Descriptor English: Complement C5b
Descriptor Spanish: Complemento C5b
Descriptor complemento C5b
Scope note: El mayor fragmento generado por la escisión de C5 por la CONVERTASA DE C5 que produce COMPLEMENTO C5A y C5b (cadena beta + cadena alfa', la cadena alfa residual, unida por un enlace disulfuro). C5b permanece unido a la membrana y comienza el ensamblaje espontáneo de los componentes tardíos del complemento para formar C5b-8-poli-C9, el COMPLEJO DE ATAQUE A LA MEMBRANA.
Descriptor Portuguese: Complemento C5b
Descriptor French: Complément C5b
Entry term(s): C5b Complement
C5b, Complement
Complement 5b
Complement Component 5b
Complement, C5b
Component 5b, Complement
Tree number(s): D12.776.124.486.274.450.625
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D050776
Scope note: The larger fragment generated from the cleavage of C5 by C5 CONVERTASE that yields COMPLEMENT C5A and C5b (beta chain + alpha' chain, the residual alpha chain, bound by disulfide bond). C5b remains bound to the membrane and initiates the spontaneous assembly of the late complement components to form C5b-8-poly-C9, the MEMBRANE ATTACK COMPLEX.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Pharm Action: Immunologic Factors
Registry Number: 80295-55-2
CAS Type 1 Name: Complement C 5b
Public MeSH Note: 2006; COMPLEMENT C5B was indexed under COMPLEMENT 5 1982-2005
History Note: 2006 (1982)
DeCS ID: 50827
Unique ID: D050776
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2006/01/01
Date of Entry: 2005/06/30
Revision Date: 2013/07/09
Complement C5b - Preferred
Concept UI M0105345
Scope note The larger fragment generated from the cleavage of C5 by C5 CONVERTASE that yields COMPLEMENT C5A and C5b (beta chain + alpha' chain, the residual alpha chain, bound by disulfide bond). C5b remains bound to the membrane and initiates the spontaneous assembly of the late complement components to form C5b-8-poly-C9, the MEMBRANE ATTACK COMPLEX.
Preferred term Complement C5b
Entry term(s) C5b Complement
C5b, Complement
Complement 5b
Complement Component 5b
Complement, C5b
Component 5b, Complement



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