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Descriptor English: Complement C5
Descriptor Spanish: Complemento C5
Descriptor complemento C5
Scope note: C5 desempeña un papel central tanto en la vía clásica como en la vía alternativa de la ACTIVACIÓN DEL COMPLEMENTO. C5 es desdoblado por la CONVERTASA C5 en COMPLEMENTO C5A y COMPLEMENTO C5B. El fragmento más pequeño C5a es una ANAFILATOXINA y mediador en el proceso inflamatorio. El fragmento mayor C5b se une a la membrana comenzando un ensamblaje espontáneo de los componentes tardíos del complemento, C5-C9, en el COMPLEJO DE ATAQUE A LA MEMBRANA.
Descriptor Portuguese: Complemento C5
Descriptor French: Complément C5
Entry term(s): C5 Complement
C5, Complement
C5, Precursor
C5, Precursor Complement
Complement 5
Complement C5, Precursor
Complement Component 5
Complement, C5
Component 5, Complement
Precursor C5
Precursor Complement C5
Pro C5
Pro complement 5
Pro-C5
Pro-complement 5
Tree number(s): D12.776.124.486.274.450
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D003182
Scope note: C5 plays a central role in both the classical and the alternative pathway of COMPLEMENT ACTIVATION. C5 is cleaved by C5 CONVERTASE into COMPLEMENT C5A and COMPLEMENT C5B. The smaller fragment C5a is an ANAPHYLATOXIN and mediator of inflammatory process. The major fragment C5b binds to the membrane initiating the spontaneous assembly of the late complement components, C5-C9, into the MEMBRANE ATTACK COMPLEX.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Pharm Action: Immunologic Factors
Previous Indexing: Complement (1968-1974)
Histamine Liberation (1966-1974)
Public MeSH Note: 2006; see COMPLEMENT 5 1978-2005, see COMPLEMENT 1975-1977; COMPLEMENT C5, PRECURSOR was indexed under COMPLEMENT 5 1991-2005
History Note: 2006 (1975)
DeCS ID: 22137
Unique ID: D003182
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1978/01/01
Date of Entry: 1974/11/11
Revision Date: 2005/07/11
Complement C5 - Preferred
Concept UI M0004937
Scope note C5 plays a central role in both the classical and the alternative pathway of COMPLEMENT ACTIVATION. C5 is cleaved by C5 CONVERTASE into COMPLEMENT C5A and COMPLEMENT C5B. The smaller fragment C5a is an ANAPHYLATOXIN and mediator of inflammatory process. The major fragment C5b binds to the membrane initiating the spontaneous assembly of the late complement components, C5-C9, into the MEMBRANE ATTACK COMPLEX.
Preferred term Complement C5
Entry term(s) C5 Complement
C5, Complement
Complement 5
Complement Component 5
Complement, C5
Component 5, Complement
Complement C5, Precursor - Broader
Concept UI M0187443
Preferred term Complement C5, Precursor
Entry term(s) C5, Precursor
C5, Precursor Complement
Precursor C5
Precursor Complement C5
Pro C5
Pro complement 5
Pro-C5
Pro-complement 5



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