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Descriptor English: Sterol Regulatory Element Binding Protein 1
Descriptor Spanish: Proteína 1 de Unión a los Elementos Reguladores de Esteroles
Descriptor proteína 1 de unión a elementos reguladores de esteroles
Scope note: Proteína de unión a los elementos reguladores de esteroles que regula la expresión de los GENES implicados en el metabolismo de los ÁCIDOS GRASOS y en la LIPOGÉNESIS. Existen dos isoformas mayores de la proteína debido al EMPALME ALTERNATIVO.
Descriptor Portuguese: Proteína de Ligação a Elemento Regulador de Esterol 1
Descriptor French: Protéine-1 de liaison à l'élément de régulation des stérols
Entry term(s): ADD1, Transcription Factor
Adipocyte Determination And Differentiation Factor 1
SRE 1 Binding Protein
SRE-1 Binding Protein
SREBP 1a
SREBP 1c
SREBP-1a
SREBP-1c
SREBP1 Protein
Sterol Regulatory Element Binding Protein 1a
Sterol Regulatory Element Binding Protein 1c
Sterol Regulatory Element-Binding Protein 1
Transcription Factor ADD1
Tree number(s): D12.776.260.103.500.750.500
D12.776.260.108.092.750.500
D12.776.930.125.500.750.500
D12.776.930.127.092.750.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D051780
Scope note: A sterol regulatory element binding protein that regulates expression of GENES involved in FATTY ACIDS metabolism and LIPOGENESIS. Two major isoforms of the protein exist due to ALTERNATIVE SPLICING.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Public MeSH Note: 2006; STEROL REGULATORY ELEMENT BINDING PROTEIN 1 was indexed under DNA-BINDING PROTEINS & TRANSCRIPTION FACTORS 1993-2005, & under CCAAT-ENHANCER-BINDING PROTEINS 2001-2005, & under NUCLEAR PROTEINS 1999-2000
History Note: 2006(1993)
DeCS ID: 50946
Unique ID: D051780
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2006/01/01
Date of Entry: 2005/06/30
Revision Date: 2009/07/17
Sterol Regulatory Element Binding Protein 1 - Preferred
Concept UI M0218287
Scope note A sterol regulatory element binding protein that regulates expression of GENES involved in FATTY ACIDS metabolism and LIPOGENESIS. Two major isoforms of the protein exist due to ALTERNATIVE SPLICING.
Preferred term Sterol Regulatory Element Binding Protein 1
Entry term(s) SRE 1 Binding Protein
SRE-1 Binding Protein
SREBP1 Protein
Sterol Regulatory Element-Binding Protein 1
Sterol Regulatory Element Binding Protein 1c - Narrower
Concept UI M0350711
Scope note SREBP1-C is an isoform of sterol regulatory element binding protein 1 that is a weak activator of GENETIC TRANSCRIPTION. It is the predominant form in LIVER and ADIPOCYTES, and it mediates INSULIN induced FATTY ACIDS synthesis.
Preferred term Sterol Regulatory Element Binding Protein 1c
Entry term(s) ADD1, Transcription Factor
Adipocyte Determination And Differentiation Factor 1
SREBP 1c
SREBP-1c
Transcription Factor ADD1
Sterol Regulatory Element Binding Protein 1a - Narrower
Concept UI M0218284
Scope note SREBP1-A is an isoform of sterol regulatory element binding protein 1 that is a potent activator of GENETIC TRANSCRIPTION. It is the predominant form in SPLEEN.
Preferred term Sterol Regulatory Element Binding Protein 1a
Entry term(s) SREBP 1a
SREBP-1a



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