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Descriptor English: Glial Cell Line-Derived Neurotrophic Factor
Descriptor Spanish: Factor Neurotrófico Derivado de la Línea Celular Glial
Descriptor factor neurotrófico derivado de células gliales
Entry term(s) GCLDNF
GDNF
factor neurotrófico derivado de la glía
factor neurotrófico derivado de la línea celular glial
factor neurotrófico derivado de las células gliales
Scope note: Miembro fundamental de la familia de factores neurotróficos derivados de la línea celular glial. En un principio se caracterizó como un FACTOR DE CRECIMIENTO NEURAL que promovía la supervivencia de las NEURONAS dopaminérgicas del MESENCÉFALO, siendo objeto de estudio como posible tratamiento de la ENFERMEDAD DE PARKINSON.
Descriptor Portuguese: Fator Neurotrófico Derivado de Linhagem de Célula Glial
Descriptor French: Facteur neurotrophique dérivé des cellules gliales
Entry term(s): Factor, Glial-Derived Neurotrophic
GDNF
GDNF Growth Factor
Glial Cell Derived Neurotrophic Factor
Glial Cell Line Derived Neurotrophic Factor
Glial Cell-Derived Neurotrophic Factor
Glial Cell-Line Derived Neurotrophic Factor
Glial Derived Neurotrophic Factor
Glial-Derived Neurotrophic Factor
Growth Factor, GDNF
Neurotrophic Factor, Glial-Derived
Tree number(s): D12.644.276.860.381.500
D12.776.467.860.381.500
D12.776.631.600.381.500
D23.529.850.381.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D051100
Scope note: The founding member of the glial cell line-derived neurotrophic factor family. It was originally characterized as a NERVE GROWTH FACTOR promoting the survival of MIDBRAIN dopaminergic NEURONS, and it has been studied as a potential treatment for PARKINSON DISEASE.
Annotation: GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTORS is also available
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Public MeSH Note: 2006; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR was indexed under NERVE GROWTH FACTORS 2003-2005, & under NERVE TISSUE PROTEINS 1993-2002
History Note: 2006(1993)
DeCS ID: 51102
Unique ID: D051100
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2006/01/01
Date of Entry: 2005/06/30
Revision Date: 2020/01/16
Glial Cell Line-Derived Neurotrophic Factor - Preferred
Concept UI M0233028
Scope note The founding member of the glial cell line-derived neurotrophic factor family. It was originally characterized as a NERVE GROWTH FACTOR promoting the survival of MIDBRAIN dopaminergic NEURONS, and it has been studied as a potential treatment for PARKINSON DISEASE.
Preferred term Glial Cell Line-Derived Neurotrophic Factor
Entry term(s) Factor, Glial-Derived Neurotrophic
GDNF
GDNF Growth Factor
Glial Cell Derived Neurotrophic Factor
Glial Cell Line Derived Neurotrophic Factor
Glial Cell-Derived Neurotrophic Factor
Glial Cell-Line Derived Neurotrophic Factor
Glial Derived Neurotrophic Factor
Glial-Derived Neurotrophic Factor
Growth Factor, GDNF
Neurotrophic Factor, Glial-Derived



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