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Descriptor English: Matrix Metalloproteinase 14
Descriptor Spanish: Metaloproteinasa 14 de la Matriz
Descriptor metaloproteinasa 14 de la matriz
Entry term(s) metaloproteinasa-14 de la matriz
Scope note: Metaloproteinasa de la matriz con dominio transmembrana. Es sintetizada como un zimógeno inactivo que es activado por la acción de las PROPROTEÍNA CONVERTASAS como la FURINA. La metaloproteinasa de la matriz 14 interviene directamente en la escisión de proteínas pericelulares. Además, funciona indirectamente activando enzimáticamente la forma proproteína de la METALOPROTEINASA 15.
Descriptor Portuguese: Metaloproteinase 14 da Matriz
Descriptor French: Matrix metalloproteinase 14
Entry term(s): MMP 14 Metalloproteinase
MMP X1 Protein
MMP-14 Metalloproteinase
MMP-X1 Protein
MMP14 Metalloproteinase
MT-MMP-1
MT1 Matrix Metalloproteinase
MT1-MMP
MT1-Matrix Metalloproteinase
Membrane Type 1 Matrix Metalloproteinase
Membrane Type Matrix Metalloproteinase 1
Membrane-Type 1 Matrix Metalloproteinase
Membrane-Type Matrix Metalloproteinase 1
Metalloproteinase 14, Matrix
Metalloproteinase, MMP-14
Metalloproteinase, MMP14
Metalloproteinase, MT1-Matrix
Tree number(s): D08.811.277.656.300.480.525.300.500
D08.811.277.656.675.374.525.300.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D053511
Scope note: A transmembrane domain-containing matrix metalloproteinase. It is synthesized as an inactive zymogen that is activated by the action of PROPROTEIN CONVERTASES such as FURIN. Matrix metalloproteinase 14 plays a direct role in the cleavage of proteins in the pericellular environment. In addition, it can function indirectly by enzymatically activating the proprotein form of MATRIX METALLOPROTEINASE 15.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Entry Combination: antagonists & inhibitors:Matrix Metalloproteinase Inhibitors
Registry Number: EC 3.4.24.80
Public MeSH Note: 2007; MATRIX METALLOPROTEINASE 14 was indexed under MATRIX METALLOPROTEINASES 2006 & under METALLOENDOPEPTIDASES 1994-2005
History Note: 2007(1994)
DeCS ID: 52233
Unique ID: D053511
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2007/01/01
Date of Entry: 2006/07/05
Revision Date: 2012/07/03
Matrix Metalloproteinase 14 - Preferred
Concept UI M0286947
Scope note A transmembrane domain-containing matrix metalloproteinase. It is synthesized as an inactive zymogen that is activated by the action of PROPROTEIN CONVERTASES such as FURIN. Matrix metalloproteinase 14 plays a direct role in the cleavage of proteins in the pericellular environment. In addition, it can function indirectly by enzymatically activating the proprotein form of MATRIX METALLOPROTEINASE 15.
Preferred term Matrix Metalloproteinase 14
Entry term(s) MMP 14 Metalloproteinase
MMP X1 Protein
MMP-14 Metalloproteinase
MMP-X1 Protein
MMP14 Metalloproteinase
MT-MMP-1
MT1 Matrix Metalloproteinase
MT1-MMP
MT1-Matrix Metalloproteinase
Membrane Type 1 Matrix Metalloproteinase
Membrane Type Matrix Metalloproteinase 1
Membrane-Type 1 Matrix Metalloproteinase
Membrane-Type Matrix Metalloproteinase 1
Metalloproteinase 14, Matrix
Metalloproteinase, MMP-14
Metalloproteinase, MMP14
Metalloproteinase, MT1-Matrix



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