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Descriptor English: Presenilin-2
Descriptor Spanish: Presenilina-2
Descriptor presenilina 2
Scope note: Proteína integral de la membrana del aparato de Golgi y del retículo endoplasmático. Su homodímero es un componente esencial del complejo gamma-secretasa que cataliza el desdoblamiento de proteínas de membrana tales como los precursores de los RECEPTORES NOTCH y de la PROTEÍNA BETA AMILOIDE. Las mutaciones en PSEN2 causan la ENFERMEDAD DE ALZHEIMER tipo 4.
Descriptor Portuguese: Presenilina-2
Descriptor French: Préséniline-2
Entry term(s): Presenilin 2
Tree number(s): D12.776.543.696.750
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D053766
Scope note: Integral membrane protein of Golgi and endoplasmic reticulum. Its homodimer is an essential component of the gamma-secretase complex that catalyzes the cleavage of membrane proteins such as NOTCH RECEPTORS and AMYLOID BETA-PEPTIDES precursors. PSEN2 mutations cause ALZHEIMER DISEASE type 4.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Alzheimer Disease (1996-2006)
Membrane Proteins (1996-2006)
Public MeSH Note: 2007; was indexed under MEMBRANE PROTEINS 1996-2006
History Note: 2007
DeCS ID: 52335
Unique ID: D053766
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2007/01/01
Date of Entry: 2006/07/05
Revision Date: 2010/06/25
Presenilin-2 - Preferred
Concept UI M0257716
Scope note Integral membrane protein of Golgi and endoplasmic reticulum. Its homodimer is an essential component of the gamma-secretase complex that catalyzes the cleavage of membrane proteins such as NOTCH RECEPTORS and AMYLOID BETA-PEPTIDES precursors. PSEN2 mutations cause ALZHEIMER DISEASE type 4.
Preferred term Presenilin-2
Entry term(s) Presenilin 2



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