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Descriptor English: Leukemia Inhibitory Factor Receptor alpha Subunit
Descriptor Spanish: Subunidad alfa del Receptor del Factor Inhibidor de Leucemia
Descriptor subunidad alfa del receptor del factor inhibidor de leucemia
Entry term(s) antígenos CD118
Scope note: Subunidad del receptor que se combina con el RECEPTOR DE CITOCINA GP130 para dar el receptor de especificidad dual para el FACTOR INHIBIDOR DE LA LEUCEMIA y la ONCOSTATINA M. Esta subunidad es también un componente del RECEPTOR DEL FACTOR NEUROTRÓFICO CILIAR. Tanto la forma que está unida a la membrana como las isoformas secretadas de la subunidad de este receptor existen merced al EMPALME ALTERNATIVO de su ARNm. Las formas secretadas se cree que actúan como un receptor inhibidor, en tanto que las formas unidas a la membrana son receptores de señalización.
Descriptor Portuguese: Subunidade alfa de Receptor de Fator Inibidor de Leucemia
Descriptor French: Sous-unité alpha du récepteur au facteur d'inhibition de la leucémie
Entry term(s): Antigen, CD118
Antigens, CD118
CD118 Antigen
CD118 Antigens
LIF Receptor alpha Subunit
Tree number(s): D12.776.543.750.705.852.583.750
D12.776.543.750.750.400.550.250.750
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D053680
Scope note: A receptor subunit that combines with CYTOKINE RECEPTOR GP130 to form the dual specificity receptor for LEUKEMIA INHIBITORY FACTOR and ONCOSTATIN M. The subunit is also a component of the CILIARY NEUROTROPHIC FACTOR RECEPTOR. Both membrane-bound and secreted isoforms of the receptor subunit exist due to ALTERNATIVE SPLICING of its mRNA. The secreted isoform is believed to act as an inhibitory receptor, while the membrane-bound form is a signaling receptor.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Public MeSH Note: 2007
History Note: 2007
DeCS ID: 52379
Unique ID: D053680
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2007/01/01
Date of Entry: 2006/07/05
Revision Date: 2017/05/24
Leukemia Inhibitory Factor Receptor alpha Subunit - Preferred
Concept UI M0495573
Scope note A receptor subunit that combines with CYTOKINE RECEPTOR GP130 to form the dual specificity receptor for LEUKEMIA INHIBITORY FACTOR and ONCOSTATIN M. The subunit is also a component of the CILIARY NEUROTROPHIC FACTOR RECEPTOR. Both membrane-bound and secreted isoforms of the receptor subunit exist due to ALTERNATIVE SPLICING of its mRNA. The secreted isoform is believed to act as an inhibitory receptor, while the membrane-bound form is a signaling receptor.
Preferred term Leukemia Inhibitory Factor Receptor alpha Subunit
Entry term(s) Antigen, CD118
Antigens, CD118
CD118 Antigen
CD118 Antigens
LIF Receptor alpha Subunit



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