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Descriptor English: Receptor, Ciliary Neurotrophic Factor
Descriptor Spanish: Receptor de Factor Neurotrófico Ciliar
Descriptor receptor del factor neurotrófico ciliar
Entry term(s) receptor CNTF
Scope note: Receptor del factor neurotrófico ciliar, constituido por tres componentes: la subunidad alfa del receptor del factor neutrofílico ciliar, el receptor del factor inhibidor de leucemia y el transductor de señal gp130. La especificidad del receptor para el factor neutrofílico ciliar está determinada por la subunidad alfa, mientras que la señal de transducción está mediada a través de la subunidad GP130. Aunque el receptor regula el desarrollo neuronal, estructuralmente es similar al receptor de citocinas para la INTERLEUCINA-6 (RECEPTORES DE INTERLEUCINA-6).
Descriptor Portuguese: Receptor do Fator Neutrófico Ciliar
Descriptor French: Récepteur facteur neurotrophique ciliaire
Entry term(s): CNTF Receptor
Ciliary Neurotrophic Factor Receptor
Receptor, CNTF
Tree number(s): D12.776.543.750.750.400.550.250
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D020801
Scope note: Cell surface receptors for CILIARY NEUROTROPHIC FACTOR. They are heterotrimeric proteins formed by the association of the CILIARY NEUROTROPHIC FACTOR RECEPTOR ALPHA SUBUNIT with the LEUKEMIA INHIBITORY FACTOR RECEPTOR ALPHA SUBUNIT and the CYTOKINE RECEPTOR GP130. Although the receptor regulates neuronal development, it is structurally similar to the cytokine receptor for INTERLEUKIN-6; (RECEPTORS, INTERLEUKIN-6).
Allowable Qualifiers: AD administration & dosage
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CH chemistry
CL classification
DE drug effects
DF deficiency
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PH physiology
RE radiation effects
TU therapeutic use
UL ultrastructure
Previous Indexing: Receptor Protein-Tyrosine Kinases (1997-1999)
Receptors, Cell Surface (1991-1999)
Receptors, Growth Factor (1993-1994)
Receptors, Nerve Growth Factor (1995-1999)
Public MeSH Note: 2000; CILIARY NEUROTROPHIC FACTOR RECEPTOR (now RECEPTOR, CILIARY NEUROTROPHIC FACTOR) was indexed under RECEPTORS, NERVE GROWTH FACTOR 1995-1999, RECEPTOR PROTEIN-TYROSINE KINASE 1997-1999, RECEPTORS, GROWTH FACTOR 1993-1994, & RECEPTORS, ENDOGENOUS SUBSTANCES 1991-1999
History Note: 2000; use RECEPTOR, CILIARY NEUROTROPHIC FACTOR (NM) 1991-1999
Entry Version: RECEPT CILIARY NEUROTROPHIC FACTOR
DeCS ID: 34501
Unique ID: D020801
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2000/01/01
Date of Entry: 1999/11/03
Revision Date: 2009/07/14
Receptor, Ciliary Neurotrophic Factor - Preferred
Concept UI M0328260
Scope note Cell surface receptors for CILIARY NEUROTROPHIC FACTOR. They are heterotrimeric proteins formed by the association of the CILIARY NEUROTROPHIC FACTOR RECEPTOR ALPHA SUBUNIT with the LEUKEMIA INHIBITORY FACTOR RECEPTOR ALPHA SUBUNIT and the CYTOKINE RECEPTOR GP130. Although the receptor regulates neuronal development, it is structurally similar to the cytokine receptor for INTERLEUKIN-6; (RECEPTORS, INTERLEUKIN-6).
Preferred term Receptor, Ciliary Neurotrophic Factor
Entry term(s) CNTF Receptor
Ciliary Neurotrophic Factor Receptor
Receptor, CNTF



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