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Descriptor English: Glutaredoxins
Descriptor Spanish: Glutarredoxinas
Descriptor glutarredoxinas
Entry term(s) glutarredoxina
Scope note: Familia de tioltransferasas que contienen dos residuos de CISTEINA en el sitio activo, en forma disulfuro (forma oxidada) o ditiol (forma reducida). Funcionan como portador de electrones en la síntesis, dependiente de GLUTIONA, de desoxirribonucleótidos por RIBONUCLEÓTIDO REDUCTASAS y pueden intervenir en la desglutationilación de los tioles en proteínas. Las formas oxidadas de las glutarredoxinas son reducidas directamente por el GLUTATIÓN.
Descriptor Portuguese: Glutarredoxinas
Descriptor French: Glutarédoxines
Entry term(s): Glutaredoxin
Glutaredoxin 1
Glutaredoxin 2
Glutaredoxin 3
Glutaredoxin 5
TTase 1
TTase-1
Thioltransferase
Thioltransferase 1
Thioltransferase-1
Tree number(s): D08.811.682.667.084
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D054477
Scope note: A family of thioltransferases that contain two active site CYSTEINE residues, which either form a disulfide (oxidized form) or a dithiol (reduced form). They function as an electron carrier in the GLUTHIONE-dependent synthesis of deoxyribonucleotides by RIBONUCLEOTIDE REDUCTASES and may play a role in the deglutathionylation of protein thiols. The oxidized forms of glutaredoxins are directly reduced by the GLUTATHIONE.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Public MeSH Note: 2008; GLUTAREDOXINS were indexed under OXIDOREDUCTASES 2005-2007 & under PROTEINS 1979-2004; THIOLTRANSFERASE was indexed under SULFHYDRYL COMPOUNDS 1978-1981; under OXIDOREDUCTASES 1982-2004 & under PROTEIN DISULFIDE REDUCTASE (GLUTATHIONE) 2005-2007
History Note: 2008(1980); use PROTEINS 1979
DeCS ID: 52721
Unique ID: D054477
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2008/01/01
Date of Entry: 2007/07/09
Glutaredoxins - Preferred
Concept UI M0071848
Scope note A family of thioltransferases that contain two active site CYSTEINE residues, which either form a disulfide (oxidized form) or a dithiol (reduced form). They function as an electron carrier in the GLUTHIONE-dependent synthesis of deoxyribonucleotides by RIBONUCLEOTIDE REDUCTASES and may play a role in the deglutathionylation of protein thiols. The oxidized forms of glutaredoxins are directly reduced by the GLUTATHIONE.
Preferred term Glutaredoxins
Entry term(s) Glutaredoxin
Thioltransferase
Glutaredoxin 2 - Narrower
Concept UI M0071845
Preferred term Glutaredoxin 2
Glutaredoxin 5 - Narrower
Concept UI M0355171
Preferred term Glutaredoxin 5
Glutaredoxin 1 - Narrower
Concept UI M0071844
Preferred term Glutaredoxin 1
Entry term(s) TTase 1
TTase-1
Thioltransferase 1
Thioltransferase-1
Glutaredoxin 3 - Narrower
Concept UI M0071846
Preferred term Glutaredoxin 3



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