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Descriptor English: Aurora Kinase A
Descriptor Spanish: Aurora Quinasa A
Descriptor aurora cinasa A
Entry term(s) aurora A cinasas
aurora cinasas A
Scope note: Aurora cinasa que se localiza en el CENTROSOMA durante la MITOSIS y está implicada en la regulación del centrosoma y la formación del HUSO MITÓTICO. La sobreexpresión de aurora A en muchos tumores malignos sugiere su implicación directa en la TRANSFORMACIÓN NEOPLÁSICA CELULAR.
Descriptor Portuguese: Aurora Quinase A
Descriptor French: Aurora kinase A
Entry term(s): AURKA
AURORA2 Protein
Aurora A Kinase
Aurora A Kinases
Aurora Kinases A
Aurora-A Kinase
AuroraA Kinase
BTAK Protein
Breast Tumor Amplified Kinase
Breast-Tumor-Amplified Kinase
STK15 Kinase
Serine Threonine Protein Kinase 15
Serine-Threonine Protein Kinase 15
Tree number(s): D08.811.913.696.620.682.700.103.500
D12.776.167.049.500
D12.776.476.563.103.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D064096
Scope note: An aurora kinase that localizes to the CENTROSOME during MITOSIS and is involved in centrosome regulation and formation of the MITOTIC SPINDLE. Aurora A overexpression in many malignant tumor types suggests that it may be directly involved in NEOPLASTIC CELL TRANSFORMATION.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 2.7.11.1
Public MeSH Note: 2014; was indexed under PROTEIN SERINE-THREONINE KINASES 1995-2013
History Note: 2014
DeCS ID: 55301
Unique ID: D064096
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2014/01/01
Date of Entry: 2013/07/08
Aurora Kinase A - Preferred
Concept UI M0579611
Scope note An aurora kinase that localizes to the CENTROSOME during MITOSIS and is involved in centrosome regulation and formation of the MITOTIC SPINDLE. Aurora A overexpression in many malignant tumor types suggests that it may be directly involved in NEOPLASTIC CELL TRANSFORMATION.
Preferred term Aurora Kinase A
Entry term(s) AURKA
AURORA2 Protein
Aurora A Kinase
Aurora A Kinases
Aurora Kinases A
Aurora-A Kinase
AuroraA Kinase
BTAK Protein
Breast Tumor Amplified Kinase
Breast-Tumor-Amplified Kinase
STK15 Kinase
Serine Threonine Protein Kinase 15
Serine-Threonine Protein Kinase 15



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