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Descriptor English: Spike Glycoprotein, Coronavirus
Descriptor Spanish: Glicoproteína de la Espiga del Coronavirus
Descriptor glicoproteína de las espículas de coronavirus
Entry term(s) glicoproteína de espícula del coronavirus bovino
glicoproteínas de las espículas de coronavirus
Scope note: Proteína de fusión viral de clase I que forma espículas características o peplómeros, de la superficie de los virus que median la adhesión, fusión y entrada en la célula huésped. Durante la maduración viral es escindida en dos subunidades: S1, que se une a receptores de la célula huésped y S2 que media la fusión con la membrana.
Descriptor Portuguese: Glicoproteína da Espícula de Coronavírus
Descriptor French: Glycoprotéine de spicule des coronavirus
Entry term(s): Coronavirus Spike Glycoprotein
Coronavirus Spike Protein
E2 Spike Glycoprotein, Coronavirus
Glycoprotein S, Coronavirus
Spike Glycoprotein S1, Coronavirus
Spike Glycoprotein, Bovine Coronavirus
Spike Glycoproteins, Coronavirus
Spike Protein S2, Coronavirus
Spike Protein, Coronavirus
Tree number(s): D12.776.543.512.500.665
D12.776.964.970.880.910.665
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D064370
Scope note: A class I viral fusion protein that forms the characteristic spikes, or peplomers, found on the viral surface that mediate virus attachment, fusion, and entry into the host cell. During virus maturation, it is cleaved into two subunits: S1, which binds to receptors in the host cell, and S2, which mediates membrane fusion.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Membrane Glycoproteins (1991-2013)
Viral Envelope Proteins (1983-2013)
Viral Proteins (1979-1982)
Public MeSH Note: 2014; was indexed under MEMBRANE GLYCOPROTEINS 1991-2013 and VIRAL ENVELOPE PROTEINS 1991-2013
History Note: 2014
DeCS ID: 55333
Unique ID: D064370
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2014/01/01
Date of Entry: 2013/07/08
Revision Date: 2020/06/22
Spike Glycoprotein, Coronavirus - Preferred
Concept UI M0581462
Scope note A class I viral fusion protein that forms the characteristic spikes, or peplomers, found on the viral surface that mediate virus attachment, fusion, and entry into the host cell. During virus maturation, it is cleaved into two subunits: S1, which binds to receptors in the host cell, and S2, which mediates membrane fusion.
Preferred term Spike Glycoprotein, Coronavirus
Entry term(s) Coronavirus Spike Glycoprotein
Coronavirus Spike Protein
Glycoprotein S, Coronavirus
Spike Glycoproteins, Coronavirus
Spike Protein, Coronavirus
Spike Glycoprotein S1, Coronavirus - Narrower
Concept UI M0582546
Preferred term Spike Glycoprotein S1, Coronavirus
Spike Protein S2, Coronavirus - Narrower
Concept UI M0582545
Preferred term Spike Protein S2, Coronavirus
Entry term(s) E2 Spike Glycoprotein, Coronavirus
Spike Glycoprotein, Bovine Coronavirus - Narrower
Concept UI M0189269
Preferred term Spike Glycoprotein, Bovine Coronavirus



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