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Descriptor English: Sofosbuvir
Descriptor Spanish: Sofosbuvir
Descriptor sofosbuvir
Scope note: Inhibidor análogo de la uridina monofosfato de la polimerasa NS5B del VIRUS DE LA HEPATITIS C (VHC) que se utiliza como un ANTIVIRAL en el tratamiento de la HEPATITIS C CRÓNICA.
Descriptor Portuguese: Sofosbuvir
Descriptor French: Sofosbuvir
Entry term(s): 2-((5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-ylmethoxy)phenoxyphosphorylamino)propionic acid isopropyl ester
7977, PSI
GS 7977
GS-7977
GS7977
PSI 7977
PSI-7977
PSI7977
Sovaldi
Tree number(s): D03.383.742.686.850.877.500
D13.695.740.850.877.500
D13.695.827.919.877.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000069474
Scope note: A uridine monophosphate analog inhibitor of HEPATITIS C VIRUS (HCV) polymerase NS5B that is used as an ANTIVIRAL AGENT in the treatment of CHRONIC HEPATITIS C.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Antiviral Agents
Registry Number: WJ6CA3ZU8B
Public MeSH Note: 2016; SOFOSBUVIR was indexed under URIDINE MONOPHOSPHATE 2010-2015
History Note: 2016 (2010)
DeCS ID: 55930
Unique ID: D000069474
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2016/01/01
Date of Entry: 2015/07/01
Revision Date: 2016/05/31
Sofosbuvir - Preferred
Concept UI M0551450
Scope note A uridine monophosphate analog inhibitor of HEPATITIS C VIRUS (HCV) polymerase NS5B that is used as an ANTIVIRAL AGENT in the treatment of CHRONIC HEPATITIS C.
Preferred term Sofosbuvir
Entry term(s) 2-((5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-ylmethoxy)phenoxyphosphorylamino)propionic acid isopropyl ester
PSI 7977 - Narrower
Concept UI M0551451
Preferred term PSI 7977
Entry term(s) 7977, PSI
PSI-7977
PSI7977
GS-7977 - Narrower
Concept UI M0580442
Preferred term GS-7977
Entry term(s) GS 7977
GS7977
Sovaldi - Narrower
Concept UI M000599042
Preferred term Sovaldi



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