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Descriptor English: CELF1 Protein
Descriptor Spanish: Proteínas CELF1
Descriptor proteínas CELF1
Scope note: Miembro de la familia de PROTEÍNAS CELF que, en mamíferos, une elementos ricos en GU (GREs, [GU Rich Elements], o elementos ricos en guanina y uridina) y tripletes repetidos de CUG en las regiones 3'UTR de los ARNm transcritos que se someten a un recambio rápido. También se une a elementos ricos en AU en las REGIONES NO TRADUCIDAS 3' de los ARNm de JUN y FOS. Las mutaciones en el gen CELF1 humana están asociados con DISTROFIA MIOTÓNICA TIPO 1.
Descriptor Portuguese: Proteínas CELF1
Descriptor French: Protéine CELF1
Entry term(s): 2 Protein, Bruno-Like
BRUNOL2 Protein
Bruno Like 2 Protein
Bruno-Like 2 Protein
CUG Triplet Repeat, RNA Binding Protein 1
CUG Triplet Repeat, RNA-Binding Protein 1
CUGBP, Elav Like Family Member 1 Protein
CUGBP, Elav-Like Family Member 1 Protein
CUGBP1 Protein
Protein, BRUNOL2
Protein, Bruno-Like 2
Protein, CELF1
Protein, CUGBP1
Tree number(s): D12.776.157.725.813.250.500
D12.776.664.962.813.250.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000067879
Scope note: A member of the CELF PROTEINS family which binds GU rich elements (GREs) and CUG-triplet repeats in the 3'UTR of mammalian mRNA transcripts that undergo rapid turnover. It also binds AU-rich elements (AREs or EDEN-like) in the 3'UTR of JUN and FOS mRNAs. Mutations in the human CELF1 gene are associated with MYOTONIC DYSTROPHY type 1.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: RNA-Binding Proteins (2005-2015)
Ribonucleoproteins (1997-2004)
Public MeSH Note: 2016
History Note: 2016
DeCS ID: 55989
Unique ID: D000067879
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2016/01/01
Date of Entry: 2015/07/01
Revision Date: 2015/02/26
CELF1 Protein - Preferred
Concept UI M000601218
Scope note A member of the CELF PROTEINS family which binds GU rich elements (GREs) and CUG-triplet repeats in the 3'UTR of mammalian mRNA transcripts that undergo rapid turnover. It also binds AU-rich elements (AREs or EDEN-like) in the 3'UTR of JUN and FOS mRNAs. Mutations in the human CELF1 gene are associated with MYOTONIC DYSTROPHY type 1.
Preferred term CELF1 Protein
Entry term(s) 2 Protein, Bruno-Like
BRUNOL2 Protein
Bruno Like 2 Protein
Bruno-Like 2 Protein
CUG Triplet Repeat, RNA Binding Protein 1
CUG Triplet Repeat, RNA-Binding Protein 1
CUGBP, Elav Like Family Member 1 Protein
CUGBP, Elav-Like Family Member 1 Protein
CUGBP1 Protein
Protein, BRUNOL2
Protein, Bruno-Like 2
Protein, CELF1
Protein, CUGBP1



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