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Descriptor English: ELAV-Like Protein 1
Descriptor Spanish: Proteína 1 Similar a ELAV
Descriptor proteína 1 similar a ELAV
Scope note: Una proteína de RRM que se une a la región 3'-UTR de los ARNm aumentando su estabilidad. En las CÉLULAS MADRE EMBRIONARIAS, se une a los elementos de poli-U y elementos AU-ricos (AREs) en la 3'-UTR del ARNm objetivo, preferentemente de aquellos ARNm que no están metilados por N6-metiladenosina (m6A), estabilizándolos y promoviendo la diferenciación.
Descriptor Portuguese: Proteína Semelhante a ELAV 1
Descriptor French: Protéine-1 similaire à ELAV
Entry term(s): Antigen, HuR
ELAV Like Protein 1
ELAVL1 protein
HuR Antigen
HuR Paraneoplastic Encephalomyelitis Antigen
HuR Protein
Protein, HuR
protein, ELAVL1
Tree number(s): D12.776.157.725.813.500.250
D12.776.664.962.813.500.250
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000067780
Scope note: An RRM protein that binds to the 3'-UTR region of mRNAs and increases their stability. In EMBRYONIC STEM CELLS, it binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs and preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), to stabilize them and promote differentiation.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: ELAV Proteins (2005-2015)
RNA-Binding Proteins (2000-2015)
Public MeSH Note: 2016; see HU PARANEOPLASTIC ENCEPHALOMYELITIS ANTIGENS 2012-2015
History Note: 2016; use ELAV PROTEINS 2012-2015
DeCS ID: 55990
Unique ID: D000067780
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2016/01/01
Date of Entry: 2015/07/10
Revision Date: 2015/07/10
ELAV-Like Protein 1 - Preferred
Concept UI M0553966
Scope note An RRM protein that binds to the 3'-UTR region of mRNAs and increases their stability. In EMBRYONIC STEM CELLS, it binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs and preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), to stabilize them and promote differentiation.
Preferred term ELAV-Like Protein 1
Entry term(s) Antigen, HuR
ELAV Like Protein 1
ELAVL1 protein
HuR Antigen
HuR Paraneoplastic Encephalomyelitis Antigen
HuR Protein
Protein, HuR
protein, ELAVL1



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