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Descriptor English: MutL Protein Homolog 1
Descriptor Spanish: Homólogo 1 de la Proteína MutL
Descriptor homólogo 1 de la proteína MutL
Entry term(s) homólogo 1 de MutL
proteína COCA2
proteína MLH1
proteína del cáncer de colon no relacionado con poliposis tipo 2
Scope note: Homólogo eucariótico de la proteína bacteriana MutL que actúa en la REPARACIÓN DEL EMPAREJAMIENTO INCORRECTO DEL DNA. Heterodimeriza con la ENDONUCLEASA PMS2 DE REPARACIÓN DEL EMPAREJAMIENTO INCORRECTO formando MutL alfa, que es reclutada en los lugares de apareamientos incorrectos por la PROTEÍNA MUTS DE UNIÓN AL EMPAREJAMIENTO INCORRECTO DE ADN. Las mutaciones en el gen MLH1S se asocian a NEOPLASIAS COLORECTALES HEREDITARIAS SIN POLIPOSIS.
Descriptor Portuguese: Proteína 1 Homóloga a MutL
Descriptor French: Protéine-1 homologue de MutL
Entry term(s): COCA2 Protein
Colon Cancer, Nonpolyposis Type 2 Protein
MLH1 Protein
MutL Homolog 1
Tree number(s): D08.811.074.766.500
D08.811.277.040.025.215.500
D12.776.260.540.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000070957
Scope note: Eukaryotic homolog of the bacterial MutL DNA MISMATCH REPAIR protein. It heterodimerizes with MISMATCH REPAIR ENDONUCLEASE PMS2 to form MutL alpha, which is recruited to DNA mismatch sites by the MUTS DNA MISMATCH-BINDING PROTEIN. Mutations in the human MLH1 gene are associated with COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 3.6.1.3
Previous Indexing: Adaptor Proteins, Signal Transducing (1994-2016)
Nuclear Proteins (1995-2016)
Public MeSH Note: 2017
History Note: 2017
DeCS ID: 56467
Unique ID: D000070957
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2016/02/26
MutL Protein Homolog 1 - Preferred
Concept UI M000612746
Scope note Eukaryotic homolog of the bacterial MutL DNA MISMATCH REPAIR protein. It heterodimerizes with MISMATCH REPAIR ENDONUCLEASE PMS2 to form MutL alpha, which is recruited to DNA mismatch sites by the MUTS DNA MISMATCH-BINDING PROTEIN. Mutations in the human MLH1 gene are associated with COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS.
Preferred term MutL Protein Homolog 1
Entry term(s) COCA2 Protein
Colon Cancer, Nonpolyposis Type 2 Protein
MLH1 Protein
MutL Homolog 1



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