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Descriptor English: Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases
Descriptor Spanish: Fosfatidilinositol-3,4,5-Trifosfato 5-Fosfatasas
Descriptor fosfatidilinositol-3,4,5-trifosfato 5 fosfatasas
Entry term(s) fosfatasas SHIP
fosfatidilinositol-3,4,5-trisfosfato 5-fosfatasas
inositol fosfatasas que contienen dominios con homología Src 2
Scope note: Fosfoinosítido fosfatasas que catalizan la desfosforilación (hidrólisis) del fosfatidilinositol-3,4,5-trifosfato (PtdIns(3,4,5)) para producir PtdIns(3,4)P(2) que regula de forma negativa las vías de PI3K (PROTEÍNAS QUINASAS DEPENDIENTES DE 3-FOSFOINOSÍTIDO). Contienen un DOMINIO SH2 y un MOTIVO ALFA ESTÉRIL. Tienen funciones importantes en la regulación de la respuesta inmunitaria y de otros procesos celulares en vertebrados.
Descriptor Portuguese: Fosfatidilinositol-3,4,5-Trifosfato 5-Fosfatases
Descriptor French: Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatases
Entry term(s): Phosphatases, SHIP
SHIP Phosphatases
Src Homology 2 Domain Containing Inositol Phosphatases
Src Homology 2 Domain-Containing Inositol Phosphatases
Tree number(s): D08.811.277.352.650.624.750
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000072183
Scope note: Phosphoinositide phosphatases that catalyze the dephosphorylation (hydrolysis) of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P(3)) to produce PtdIns(3,4)P(2), which negatively regulates the PI3K ( 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASES) pathways. They contain an SH2 DOMAIN and STERILE ALPHA MOTIF and have important functions in regulating the immune response and other cellular processes in vertebrates.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 3.1.3.86
Previous Indexing: Phosphoric Monoester Hydrolases (1996-2016)
Public MeSH Note: 2017
History Note: 2017
DeCS ID: 56477
Unique ID: D000072183
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2016/07/01
Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases - Preferred
Concept UI M000616490
Scope note Phosphoinositide phosphatases that catalyze the dephosphorylation (hydrolysis) of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P(3)) to produce PtdIns(3,4)P(2), which negatively regulates the PI3K ( 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASES) pathways. They contain an SH2 DOMAIN and STERILE ALPHA MOTIF and have important functions in regulating the immune response and other cellular processes in vertebrates.
Preferred term Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases
Entry term(s) Phosphatases, SHIP
SHIP Phosphatases
Src Homology 2 Domain Containing Inositol Phosphatases
Src Homology 2 Domain-Containing Inositol Phosphatases



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