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Descriptor English: Src Homology 2 Domain-Containing, Transforming Protein 1
Descriptor Spanish: Proteína Transformadora 1 que Contiene Dominios de Homología 2 de Src
Descriptor proteína transformadora 1 que contiene dominios de homología 2 de Src
Entry term(s) proteína SHC1
proteína SHC1 (que contiene dominios de homología 2 de Src)
proteína ShcA
proteína transformadora C1 con dominios de homología 2 de Src
proteína transformadora SHC-1
Scope note: Proteína adaptadora de la señalización SHC que transduce las señales dependientes de FOSFOTIROSINA más allá de las PROTEÍNAS TIROSINA QUINASAS RECEPTORAS y tirosina quinasas no-receptoras. Es necesaria para la MIGRACIÓN CELULAR inducida por TGF-BETA, la INVASIVIDAD NEOPLÁSICA y en las METÁSTASIS de las NEOPLASIAS DE LA MAMA. Su dominio SH2 es esencial para la supervivencia del tumor. También participa en la señalización descendente del RECEPTOR TIE-2 DE ANGIOPOYETINA, regulando la migración de las CÉLULAS ENDOTELIALES y en la NEOVASCULARIZACIÓN FISIOLÓGICA.
Descriptor Portuguese: Proteína 1 de Transformação que Contém Domínio 2 de Homologia de Src
Descriptor French: Protéine transformante-1 contenant un domaine d'homologie-2 de Src
Entry term(s): SHC (Src Homology 2 Domain-Containing) Transforming Protein 1
SHC Transforming Protein 1
SHC-Transforming Protein 1
SHC1 (Src Homology 2 Domain-Containing) Protein
SHC1 Protein
ShcA Protein
Src Homology 2 Domain Containing Transforming Protein C1
Src Homology 2 Domain Containing, Transforming Protein 1
Src Homology 2 Domain-Containing-Transforming Protein C1
Tree number(s): D12.644.360.024.330.500
D12.776.157.057.162.500
D12.776.476.024.424.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000071425
Scope note: An SHC-signaling adaptor protein that transduces PHOSPHOTYROSINE-dependent signals downstream of RECEPTOR PROTEIN-TYROSINE KINASES and non-receptor tyrosine kinases. It is required for TGF-BETA-induced CELL MIGRATION; NEOLPASM INVASION; and METASTASIS of BREAST NEOPLASMS; its SH2 DOMAIN is essential for tumor survival. It also functions in signaling downstream of ANGIOPOIETIN RECEPTOR TIE-2, regulating the migration of ENDOTHELIAL CELLS; and PHYSIOLOGIC NEOVASCULARIZATION.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Public MeSH Note: 2017; see SHC SIGNALING ADAPTOR PROTEINS 2009-2016
History Note: 2017; use SHC SIGNALING ADAPTOR PROTEINS 2009-2016
DeCS ID: 56539
Unique ID: D000071425
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2016/04/15
Src Homology 2 Domain-Containing, Transforming Protein 1 - Preferred
Concept UI M0454582
Scope note An SHC-signaling adaptor protein that transduces PHOSPHOTYROSINE-dependent signals downstream of RECEPTOR PROTEIN-TYROSINE KINASES and non-receptor tyrosine kinases. It is required for TGF-BETA-induced CELL MIGRATION; NEOLPASM INVASION; and METASTASIS of BREAST NEOPLASMS; its SH2 DOMAIN is essential for tumor survival. It also functions in signaling downstream of ANGIOPOIETIN RECEPTOR TIE-2, regulating the migration of ENDOTHELIAL CELLS; and PHYSIOLOGIC NEOVASCULARIZATION.
Preferred term Src Homology 2 Domain-Containing, Transforming Protein 1
Entry term(s) SHC (Src Homology 2 Domain-Containing) Transforming Protein 1
SHC Transforming Protein 1
SHC-Transforming Protein 1
SHC1 (Src Homology 2 Domain-Containing) Protein
SHC1 Protein
ShcA Protein
Src Homology 2 Domain Containing Transforming Protein C1
Src Homology 2 Domain Containing, Transforming Protein 1
Src Homology 2 Domain-Containing-Transforming Protein C1



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