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Descriptor English: Dystonin
Descriptor Spanish: Distonina
Descriptor distonina
Entry term(s) antígeno 1 del penfigoide ampolloso
antígeno de 230 kDa del penfigoide ampolloso
antígeno de 230-240 kDa del penfigoide ampolloso
antígeno del penfigoide ampolloso 1
antígeno del penfigoide ampolloso de 230 kDa
antígeno del penfigoide ampolloso de 230-240 kDa
proteína de la placa del hemidesmosoma
Scope note: Plaquina caracterizada por secuencias repetidas homólogas a la ESPECTRINA y la PLECTINA y MOTIVOS EF HAND C-terminales. Funciona como integradora de los FILAMENTOS INTERMEDIOS, la ACTINA y los MICROTÚBULOS en las redes del citoesqueleto. Es necesaria para anclar los filamentos intermedios al citoesqueleto de actina en células nerviosas y musculares y los filamentos intermedios que contienen QUERATINA a los HEMIDESMOSOMAS de las CÉLULAS EPITELIALES.
Descriptor Portuguese: Distonina
Descriptor French: Dystonine
Entry term(s): 230 240 kDa Bullous Pemphigoid Antigen
230 kDa Bullous Pemphigoid Antigen
230-240 kDa Bullous Pemphigoid Antigen
Bullous Pemphigoid Antigen 1
Hemidesmosomal Plaque Protein
Tree number(s): D12.776.220.790.625
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000071821
Scope note: A plakin characterized by repeat sequences homologous to SPECTRIN and PLECTIN and C-terminal EF HAND MOTIFS. It functions as an integrator of INTERMEDIATE FILAMENTS, ACTIN and MICROTUBULES in cytoskeleton networks. It is required for anchoring intermediate filaments to the actin cytoskeleton in neural and muscle cells as well as anchoring KERATIN-containing intermediate filaments to HEMIDESMOSOMES in EPITHELIAL CELLS.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Carrier Proteins (1995-2016)
Cytoskeletal Proteins (1995-2016)
Nerve Tissue Proteins (1995-2016)
Public MeSH Note: 2017
History Note: 2017
DeCS ID: 56594
Unique ID: D000071821
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2016/04/15
Dystonin - Preferred
Concept UI M000615558
Scope note A plakin characterized by repeat sequences homologous to SPECTRIN and PLECTIN and C-terminal EF HAND MOTIFS. It functions as an integrator of INTERMEDIATE FILAMENTS, ACTIN and MICROTUBULES in cytoskeleton networks. It is required for anchoring intermediate filaments to the actin cytoskeleton in neural and muscle cells as well as anchoring KERATIN-containing intermediate filaments to HEMIDESMOSOMES in EPITHELIAL CELLS.
Preferred term Dystonin
Entry term(s) 230 240 kDa Bullous Pemphigoid Antigen
230 kDa Bullous Pemphigoid Antigen
230-240 kDa Bullous Pemphigoid Antigen
Bullous Pemphigoid Antigen 1
Hemidesmosomal Plaque Protein



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