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Descriptor English: Smoothened Receptor
Descriptor Spanish: Receptor Smoothened
Descriptor receptor Smoothened
Entry term(s) proteína Smoothened
receptores Smoothened
Scope note: Receptor similar a frizzled y acoplado a proteínas G que se asocia a los RECEPTORES PATCHED para transducir señales de las PROTEÍNAS HEDGEHOG e iniciar la vía de señalización de Hedgehog en la PROTEÍNA CON DEDOS DE ZINC GLI1. Normalmente inhibe la señalización si no hay una PROTEÍNA SONIC HEDGEHOG unida al RECEPTOR PATCHED-1.
Descriptor Portuguese: Receptor Smoothened
Descriptor French: Récepteur Smoothened
Entry term(s): Receptor, Smoothened
Receptors, Smoothened
Smoothened Protein
Smoothened Receptors
Tree number(s): D12.776.543.750.695.017.500
D12.776.543.750.850.500.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000072086
Scope note: A frizzled-like, G-protein-coupled receptor that associates with PATCHED RECEPTORS to transduce signals from HEDGEHOG PROTEINS and initiate hedgehog signaling to ZINC FINGER PROTEIN GLI1. It may normally inhibit signaling in the absence of SONIC HEDGEHOG PROTEIN binding to PATCHED RECEPTOR-1.
Allowable Qualifiers: AD administration & dosage
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CH chemistry
CL classification
DE drug effects
DF deficiency
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PH physiology
RE radiation effects
TU therapeutic use
UL ultrastructure
Previous Indexing: Receptors, G-Protein-Coupled (2004-2016)
Public MeSH Note: 2017
History Note: 2017
DeCS ID: 56644
Unique ID: D000072086
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2016/05/27
Smoothened Receptor - Preferred
Concept UI M000616322
Scope note A frizzled-like, G-protein-coupled receptor that associates with PATCHED RECEPTORS to transduce signals from HEDGEHOG PROTEINS and initiate hedgehog signaling to ZINC FINGER PROTEIN GLI1. It may normally inhibit signaling in the absence of SONIC HEDGEHOG PROTEIN binding to PATCHED RECEPTOR-1.
Preferred term Smoothened Receptor
Entry term(s) Receptor, Smoothened
Receptors, Smoothened
Smoothened Protein
Smoothened Receptors



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