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Descriptor English: Patched-1 Receptor
Descriptor Spanish: Receptor Patched-1
Descriptor receptor Patched 1
Entry term(s) homólogo 1 de Patched
proteína PTCH1
proteína Patched-1
receptor Patched-1
Scope note: Receptor patched para diversas PROTEÍNAS HEDGEHOG que se asocia con el RECEPTOR SMOOTHENED para modular la vía de señalización de Hedgehog. También es una PROTEÍNA SUPRESORA DE TUMORES. Las mutaciones en el gen patched-1 se asocian al SÍNDROME DEL NEVO BASOCELULAR, al CARCINOMA DE CÉLULAS ESCAMOSAS DEL ESÓFAGO, a tricoepiteliomas y al CARCINOMA DE CÉLULAS TRANSICIONALES de la VEJIGA URINARIA.
Descriptor Portuguese: Receptor Patched-1
Descriptor French: Récepteur Patched-1
Entry term(s): PTCH1 Protein
Patched 1 Protein
Patched 1 Receptor
Patched Homolog 1
Patched Homolog-1
Patched Receptor 1
Patched Receptor-1
Patched-1 Protein
Receptor, Patched-1
Receptor-1, Patched
Tree number(s): D12.776.543.750.058.500
D12.776.624.776.633.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000072081
Scope note: A patched receptor for several HEDGEHOG PROTEINS that associates with the SMOOTHENED RECEPTOR to modulate hedgehog signaling. It is also a TUMOR SUPPRESSOR PROTEIN; mutations in the patched-1 gene are associated with BASAL CELL NEVUS SYNDROME; SQUAMOUS CELL CARCNIOMA of the ESOPHAGUS; trichoepitheliomas, and CARCINOMA, TRANSITIONAL CELL of the URINARY BLADDER.
Allowable Qualifiers: AD administration & dosage
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CH chemistry
CL classification
DE drug effects
DF deficiency
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PH physiology
RE radiation effects
TU therapeutic use
UL ultrastructure
Public MeSH Note: 2017; PATCHED-1 RECEPTOR was indexed under RECEPTORS, CELL SURFACE 2005-2016, and under MEMBRANE PROTEINS 1996-2005
History Note: 2017 (1996)
DeCS ID: 56641
Unique ID: D000072081
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2016/05/27
Patched-1 Receptor - Preferred
Concept UI M000616305
Scope note A patched receptor for several HEDGEHOG PROTEINS that associates with the SMOOTHENED RECEPTOR to modulate hedgehog signaling. It is also a TUMOR SUPPRESSOR PROTEIN; mutations in the patched-1 gene are associated with BASAL CELL NEVUS SYNDROME; SQUAMOUS CELL CARCNIOMA of the ESOPHAGUS; trichoepitheliomas, and CARCINOMA, TRANSITIONAL CELL of the URINARY BLADDER.
Preferred term Patched-1 Receptor
Entry term(s) PTCH1 Protein
Patched 1 Protein
Patched 1 Receptor
Patched Homolog 1
Patched Homolog-1
Patched Receptor 1
Patched Receptor-1
Patched-1 Protein
Receptor, Patched-1
Receptor-1, Patched



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