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Descriptor English: Histone Deacetylase 6
Descriptor Spanish: Histona Desacetilasa 6
Descriptor histona desacetilasa 6
Scope note: Histona desacetilasa de clase II que elimina grupos acetilo de las LISINAS N-terminales de la HISTONA H2A, HISTONA H2B, HISTONA H3 e HISTONA H4. Tiene un papel crítico en la REPRESIÓN EPIGENÉTICA y en la regulación de la TRANSCRIPCIÓN GENÉTICA, así como en la MOTILIDAD CELULAR mediante la desacetilación de la TUBULINA. También dirige a las proteínas mal plegadas hacia su eliminación por AUTOFAGIA cuando la capacidad del plegamiento mediado por CHAPERONAS MOLECULARES se sobrepasa.
Descriptor Portuguese: Desacetilase 6 de Histona
Descriptor French: Histone deacetylase 6
Tree number(s): D08.811.277.087.520.350
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000073864
Scope note: A class II histone deacetylase that removes acetyl groups from N-terminal LYSINES of HISTONE H2A; HISTONE H2B; HISTONE H3; and HISTONE H4. It plays a critical role in EPIGENETIC REPRESSION and regulation of GENETIC TRANSCRIPTION, as well as CELL MOTILITY through deacetylation of TUBULIN. It also targets misfolded proteins for clearance by AUTOPHAGY when MOLECULAR CHAPERONE-mediated folding is overwhelmed.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 3.5.1.98
Previous Indexing: Histone Deacetylases (2001-2017)
Public MeSH Note: 2018
History Note: 2018
DeCS ID: 57003
Unique ID: D000073864
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2017/01/17
Histone Deacetylase 6 - Preferred
Concept UI M000624133
Scope note A class II histone deacetylase that removes acetyl groups from N-terminal LYSINES of HISTONE H2A; HISTONE H2B; HISTONE H3; and HISTONE H4. It plays a critical role in EPIGENETIC REPRESSION and regulation of GENETIC TRANSCRIPTION, as well as CELL MOTILITY through deacetylation of TUBULIN. It also targets misfolded proteins for clearance by AUTOPHAGY when MOLECULAR CHAPERONE-mediated folding is overwhelmed.
Preferred term Histone Deacetylase 6



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