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Descriptor English: Anoctamin-1
Descriptor Spanish: Anoctamina-1
Descriptor anoctamina-1
Entry term(s) proteína TMEM16A
proteína transmembranaria 16A
Scope note: Canal de cloruro anoctamina expresado en altas concentraciones en el hígado, músculo esquelético y musculatura del tubo digestivo y que actúa en el transporte transepitelial de aniones y en la contracción del músculo liso. Es esencial para el funcionamiento de las CÉLULAS INTERSTICIALES DE CAJAL y tiene un papel importante en la conducción de cloruro en las células epiteliales de las vías aéreas y en el desarrollo del cartílago traqueal.
Descriptor Portuguese: Anoctamina-1
Descriptor French: Anoctamine-1
Entry term(s): Anoctamin 1
TMEM16A Protein
Transmembrane Protein 16A
Tree number(s): D12.776.157.530.400.175.032.500
D12.776.543.550.450.175.032.500
D12.776.543.585.400.175.032.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000075369
Scope note: An anoctamin chloride channel expressed at high levels in the liver, skeletal muscle, and gastrointestinal muscles that functions in transepithelial anion transport and smooth muscle contraction. It is essential for the function of the INTERSTITIAL CELLS OF CAJAL and plays a major role in chloride conduction by airway epithelial cells and in tracheal cartilage development.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Chloride Channels (2003-2017)
Public MeSH Note: 2018
History Note: 2018
DeCS ID: 57080
Unique ID: D000075369
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2017/05/24
Anoctamin-1 - Preferred
Concept UI M000630246
Scope note An anoctamin chloride channel expressed at high levels in the liver, skeletal muscle, and gastrointestinal muscles that functions in transepithelial anion transport and smooth muscle contraction. It is essential for the function of the INTERSTITIAL CELLS OF CAJAL and plays a major role in chloride conduction by airway epithelial cells and in tracheal cartilage development.
Preferred term Anoctamin-1
Entry term(s) Anoctamin 1
TMEM16A Protein
Transmembrane Protein 16A



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