| Descriptor English: | Rosiglitazone | ||||||
| Descriptor Spanish: | Rosiglitazona 
 | ||||||
| Descriptor Portuguese: | Rosiglitazona | ||||||
| Descriptor French: | Rosiglitazone | ||||||
| Entry term(s): | 5-((4-(2-Methyl-2-(pyridinylamino)ethoxy)phenyl)methyl)-2,4-thiazolidinedione-2-butenedioate Avandia BRL 49653 BRL-49653 BRL49653 Rosiglitazone Maleate | ||||||
| Tree number(s): | D02.886.675.933.500 D03.383.129.708.933.500 | ||||||
| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D000077154 | ||||||
| Scope note: | A thiazolidinedione that functions as a selective agonist for PPAR GAMMA. It improves INSULIN SENSITIVITY in adipose tissue, skeletal muscle, and the liver of patients with TYPE 2 DIABETES MELLITUS. | ||||||
| Allowable Qualifiers: | AA                                                            analogs & derivatives AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis EC economics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UR urine | ||||||
| Pharm Action: | Hypoglycemic Agents | ||||||
| Registry Number: | 05V02F2KDG | ||||||
| CAS Type 1 Name: | 2,4-Thiazolidinedione, 5-((4-(2-(methyl-2-pyridinylamino)ethoxy)phenyl)methyl)- | ||||||
| Public MeSH Note: | 2019; ROSIGLITAZONE was indexed under THIAZOLIDINEDIONES 2004-2018, and under THIAZOLES 1994-2003 | ||||||
| History Note: | 2019 (1994) | ||||||
| Related: | Pioglitazone
                                            MeSH | ||||||
| DeCS ID: | 57524 | ||||||
| Unique ID: | D000077154 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2019/01/01 | ||||||
| Date of Entry: | 2018/07/09 | ||||||
| Revision Date: | 2018/07/02 | 
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                                        CHEMICALS AND DRUGS
 
 Organic Chemicals [D02]Organic Chemicals
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 CHEMICALS AND DRUGS
 Heterocyclic Compounds [D03]Heterocyclic Compounds
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                        Rosiglitazone                                            
                                        - Preferred                                        
                                                                
                                
                        
                        
                        
                                                                    
                        Rosiglitazone Maleate                                            
                                        - Narrower                                        
                                                                
                                
                                                                    
                        5-((4-(2-Methyl-2-(pyridinylamino)ethoxy)phenyl)methyl)-2,4-thiazolidinedione-2-butenedioate                                            
                                        - Narrower                                        
                                                                
                                
                                                                    
                        Avandia                                            
                                        - Narrower                                        
                                                                
                                
                                                                    
                        BRL 49653                                            
                                        - Narrower                                        
                                                                
                                
                        
                        
                    
                    
                
                | Concept UI | M0237199 | 
| Scope note | A thiazolidinedione that functions as a selective agonist for PPAR GAMMA. It improves INSULIN SENSITIVITY in adipose tissue, skeletal muscle, and the liver of patients with TYPE 2 DIABETES MELLITUS. | 
| Preferred term | Rosiglitazone | 
| Concept UI | M0398223 | 
| Preferred term | Rosiglitazone Maleate | 
| Concept UI | M000639464 | 
| Preferred term | 5-((4-(2-Methyl-2-(pyridinylamino)ethoxy)phenyl)methyl)-2,4-thiazolidinedione-2-butenedioate | 
| Concept UI | M0359368 | 
| Preferred term | Avandia | 
| Concept UI | M0237200 | 
| Preferred term | BRL 49653 | 
| Entry term(s) | BRL-49653 BRL49653 | 
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