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Descriptor English: Troglitazone
Descriptor Spanish: Troglitazona
Descriptor troglitazona
Entry term(s) 5-(4-((6-hidroxi-2,5,7,8-tetrametilcroman-2-il-metoxi)bencil)-2,4-tiazolidinediona) - T
CS 045
CS-045
CS045
prelay
rezulin
Scope note: Derivado de cromano y tiazolidinediona que actúa como agonista de los RECEPTORES ACTIVADOS POR PROLIFERADORES DE PEROXISOMAS (PPAR). Anteriormente se usaba en el tratamiento de la DIABETES MELLITUS DE TIPO 2, pero se ha retirado debido a su hepatotoxicidad.
Descriptor Portuguese: Troglitazona
Descriptor French: Troglitazone
Entry term(s): 5-(4-((6-Hydroxy-2,5,7,8-tetramethylchroman-2-yl-methoxy)benzyl)-2,4-thiazolidinedione) - T
CS 045
CS-045
CS045
Prelay
Rezulin
Tree number(s): D02.886.675.933.750
D03.383.129.708.933.750
D03.383.663.283.240.612
D03.633.100.150.240.612
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000077288
Scope note: A chroman and thiazolidinedione derivative that acts as a PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS (PPAR) agonist. It was formerly used in the treatment of TYPE 2 DIABETES MELLITUS, but has been withdrawn due to hepatotoxicity.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Hypoglycemic Agents
Registry Number: I66ZZ0ZN0E
CAS Type 1 Name: 2,4-Thiazolidinedione, 5-((4-((3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy)phenyl)methyl)-
Public MeSH Note: 2019; TROGLITAZONE was indexed under CHROMANS and THIAZOLIDINEDIONES 2004-2018; and under THIAZOLES 1988-2003
History Note: 2019 (1988)
DeCS ID: 57589
Unique ID: D000077288
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2019/01/01
Date of Entry: 2018/07/09
Revision Date: 2018/02/27
Troglitazone - Preferred
Concept UI M000640328
Scope note A chroman and thiazolidinedione derivative that acts as a PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS (PPAR) agonist. It was formerly used in the treatment of TYPE 2 DIABETES MELLITUS, but has been withdrawn due to hepatotoxicity.
Preferred term Troglitazone
Entry term(s) 5-(4-((6-Hydroxy-2,5,7,8-tetramethylchroman-2-yl-methoxy)benzyl)-2,4-thiazolidinedione) - T
CS 045 - Narrower
Concept UI M0161287
Preferred term CS 045
Entry term(s) CS-045
CS045
Rezulin - Narrower
Concept UI M0161289
Preferred term Rezulin
Prelay - Narrower
Concept UI M0398828
Preferred term Prelay



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