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Descriptor English: Wortmannin
Descriptor Spanish: Wortmanina
Descriptor wortmanina
Entry term(s) MS 54
MS-54
MS54
Scope note: Metabolito androstadiénico producido por los hongos PENICILLIUM funiculosum que inhibe la FOSFATIDILINOSITOL-3-CINASA y la activación específica del aloantígeno de los LINFOCITOS T en líneas celulares tumorales humanas. Se utiliza a menudo en investigación en BIOLOGÍA CELULAR y tiene un amplio potencial terapéutico.
Descriptor Portuguese: Wortmanina
Descriptor French: Wortmannine
Entry term(s): MS 54
MS-54
MS54
Tree number(s): D04.210.500.054.079.129.891
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000077191
Scope note: An androstadiene metabolite produced by the fungi PENICILLIUM funiculosum that inhibits PHOSPHATIDYLINOSITOL-3-KINASES and alloantigen-specific activation of T-LYMPHOCYTES in human tumor cell lines. It is widely used in CELL BIOLOGY research and has broad therapeutic potential.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Antifungal Agents
Immunosuppressive Agents
Insulin Antagonists
Radiation-Sensitizing Agents
Protein Kinase Inhibitors
Registry Number: XVA4O219QW
CAS Type 1 Name: (1 alpha,11 alpha)-11-(Acetyloxy)-1-(methoxymethyl)-2-oxaandrosta-5,8-dieno(6,5,4-bc)furan- 3,7,17-trione
Public MeSH Note: 2019; WORTMANNIN was indexed under ANDROSTADIENES 1980-2018, and under COUMARINS and INDENES 1974-1979
History Note: 2019 (1974)
DeCS ID: 57533
Unique ID: D000077191
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2019/01/01
Date of Entry: 2018/07/09
Revision Date: 2018/06/19
Wortmannin - Preferred
Concept UI M0054588
Scope note An androstadiene metabolite produced by the fungi PENICILLIUM funiculosum that inhibits PHOSPHATIDYLINOSITOL-3-KINASES and alloantigen-specific activation of T-LYMPHOCYTES in human tumor cell lines. It is widely used in CELL BIOLOGY research and has broad therapeutic potential.
Preferred term Wortmannin
MS 54 - Narrower
Concept UI M0054586
Preferred term MS 54
Entry term(s) MS-54
MS54



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