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Descriptor English: Leflunomide
Descriptor Spanish: Leflunamida
Descriptor leflunomida
Entry term(s) Arava
HWA 486
HWA-486
HWA486
N-(4-trifluorometilfenil)-5-metilisoxazol-4-carboxamida
SU101
Scope note: Derivado isoxazólico que inhibe la dihidroorotato deshidrogenasa, la cuarta enzima de la ruta de biosíntesis de pirimidinas. Se usa como inmunosupresor en el tratamiento de la ARTRITIS REUMATOIDE y de la ARTRITIS PSORIÁSICA.
Descriptor Portuguese: Leflunomida
Descriptor French: Léflunomide
Entry term(s): Arava
HWA 486
HWA-486
HWA486
N-(4-Trifluoromethyphenyl)-5-methylisoxazole-4-carboxamide
SU101
Tree number(s): D03.383.129.385.475
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000077339
Scope note: An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Enzyme Inhibitors
Immunosuppressive Agents
Registry Number: G162GK9U4W
CAS Type 1 Name: 4-Isoxazolecarboxamide, 5-methyl-N-(4-(trifluoromethyl)phenyl)-
Public MeSH Note: 2019; LEFLUNOMIDE was indexed under ISOXAZOLES 1991-2018; and under OXAZOLES 1985-1990
History Note: 2019 (1985)
DeCS ID: 57623
Unique ID: D000077339
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2019/01/01
Date of Entry: 2018/07/09
Revision Date: 2018/02/27
Leflunomide - Preferred
Concept UI M0132172
Scope note An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
Preferred term Leflunomide
Entry term(s) N-(4-Trifluoromethyphenyl)-5-methylisoxazole-4-carboxamide
HWA 486 - Narrower
Concept UI M0132169
Preferred term HWA 486
Entry term(s) HWA-486
HWA486
SU101 - Narrower
Concept UI M0391288
Preferred term SU101
Arava - Narrower
Concept UI M0398614
Preferred term Arava



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