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Descriptor English: Homoharringtonine
Descriptor Spanish: Homoharringtonina
Descriptor homoharringtonina
Entry term(s) Ceflatonin
Synribo
cefalotaxina
isómero (3(R)) de la homoharringtonina
mepesuccinato de omacetaxina
omacetaxina
Scope note: Derivado semisintético de la harringtonina que actúa como inhibidor de la síntesis de proteínas e induce la APOPTOSIS en las células tumorales. Se usa en el tratamiento de la LEUCEMIA MIELOIDE crónica.
Descriptor Portuguese: Mepesuccinato de Omacetaxina
Descriptor French: Homoharringtonine
Entry term(s): Ceflatonin
Cephalotaxine
Homoharringtonine (3(R))-isomer
Omacetaxine
Omacetaxine Mepesuccinate
Synribo
Tree number(s): D03.132.420.500
D03.633.100.079.533.500
D03.633.400.624.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000077863
Scope note: Semisynthetic derivative of harringtonine that acts as a protein synthesis inhibitor and induces APOPTOSIS in tumor cells. It is used in the treatment of MYELOID LEUKEMIA, CHRONIC.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Antineoplastic Agents, Phytogenic
Protein Synthesis Inhibitors
Registry Number: 6FG8041S5B
CAS Type 1 Name: Cephalotaxine, O3-((2R)-2,6-dihydroxy-2-(2-methoxy-2-oxoethyl)-6-methyl-1-oxoheptyl)-
Public MeSH Note: 2019; HOMOHARRINGTONINE was indexed under HARRINGTONINES 1978-2018; under ALKALOIDS and ANTINEOPLASTIC AGENTS 1972-1977; and under DIOXOLES 1972-1976
History Note: 2019 (1972)
DeCS ID: 57767
Unique ID: D000077863
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2019/01/01
Date of Entry: 2018/07/09
Revision Date: 2018/05/21
Homoharringtonine - Preferred
Concept UI M0041919
Scope note Semisynthetic derivative of harringtonine that acts as a protein synthesis inhibitor and induces APOPTOSIS in tumor cells. It is used in the treatment of MYELOID LEUKEMIA, CHRONIC.
Preferred term Homoharringtonine
Entry term(s) Omacetaxine Mepesuccinate
Cephalotaxine - Narrower
Concept UI M0041843
Preferred term Cephalotaxine
Entry term(s) Omacetaxine
Homoharringtonine (3(R))-isomer - Narrower
Concept UI M000642642
Preferred term Homoharringtonine (3(R))-isomer
Ceflatonin - Narrower
Concept UI M0496717
Preferred term Ceflatonin
Synribo - Narrower
Concept UI M000642641
Preferred term Synribo



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