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Descriptor English: Clonal Hematopoiesis
Descriptor Spanish: Hematopoyesis Clonal
Descriptor hematopoyesis clonal
Entry term(s) ARCH, hematopoyesis clonal relacionada con la edad
ICUS, citopenias idiopáticas de significado incierto
citopenia clonal de significado incierto
citopenia clonal de significado incierto (CCUS)
citopenias idiopáticas de significado incierto
hematopoyesis clonal de potencial indeterminado
hematopoyesis clonal de potencial indeterminado CHIP
hematopoyesis clonal relacionada con la edad
Scope note: Expansión de células sanguíneas derivadas de CÉLULAS MADRE HEMATOPOYÉTICAS mutantes a menudo relacionada con el envejecimiento. Las mutaciones en genes reguladores epigenéticos son frecuentes en la hematopoyesis clonal y pueden ser un factor de riesgo de NEOPLASIAS HEMATOLÓGICAS y de otras enfermedades cardiovasculares. Cuando la fracción alélica variante representa al menos el dos por ciento y está presente en ausencia de citopenias intensas, recibe el nombre de hematopoyesis clonal de potencial indeterminado (HCPI).
Descriptor Portuguese: Hematopoiese Clonal
Descriptor French: Hématopoïèse clonale
Entry term(s): ARCH Age related Clonal Hematopoiesis
ARCH Age-related Clonal Hematopoiesis
Age related Clonal Hematopoiesis
Age-related Clonal Hematopoiesis
CCUS Clonal Cytopenia of Undetermined Significance
CHIP Clonal Hematopoiesis of Indeterminate Potential
Clonal Cytopenia of Undetermined Significance
Clonal Hematopoiesis of Indeterminate Potential
Clonal Hematopoiesis, Age-related
Hematopoiesis, Age-related Clonal
Hematopoiesis, Clonal
ICUS Idiopathic Cytopenias of Undetermined Significance
Idiopathic Cytopenias of Undetermined Significance
Tree number(s): G04.152.825.207
G04.375.500
G05.158.500
G09.188.343.207
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000082182
Scope note: Expansion of blood cells arising from mutant HEMATOPOIETIC STEM CELLS often related to aging. Mutations on epigenetic regulator genes are common in clonal hematopoiesis and may be a risk factor for HEMATOLOGIC NEOPLASMS and other cardiovascular diseases. When variant allele fraction is at least 2% and is present in the absence of severe cytopenias it is referred to as clonal hematopoiesis of indeterminate potential (CHIP).
Allowable Qualifiers: DE drug effects
GE genetics
IM immunology
PH physiology
RE radiation effects
Previous Indexing: Hematopoiesis (1989-2020)
Public MeSH Note: 2021
History Note: 2021
DeCS ID: 59328
Unique ID: D000082182
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2021/01/01
Date of Entry: 2020/07/07
Revision Date: 2022/04/13
Clonal Hematopoiesis - Preferred
Concept UI M000675997
Scope note Expansion of blood cells arising from mutant HEMATOPOIETIC STEM CELLS often related to aging. Mutations on epigenetic regulator genes are common in clonal hematopoiesis and may be a risk factor for HEMATOLOGIC NEOPLASMS and other cardiovascular diseases. When variant allele fraction is at least 2% and is present in the absence of severe cytopenias it is referred to as clonal hematopoiesis of indeterminate potential (CHIP).
Preferred term Clonal Hematopoiesis
Entry term(s) Hematopoiesis, Clonal
Age-related Clonal Hematopoiesis - Narrower
Concept UI M000675998
Preferred term Age-related Clonal Hematopoiesis
Entry term(s) ARCH Age related Clonal Hematopoiesis
ARCH Age-related Clonal Hematopoiesis
Age related Clonal Hematopoiesis
Clonal Hematopoiesis, Age-related
Hematopoiesis, Age-related Clonal
CHIP Clonal Hematopoiesis of Indeterminate Potential - Narrower
Concept UI M000675999
Preferred term CHIP Clonal Hematopoiesis of Indeterminate Potential
Entry term(s) Clonal Hematopoiesis of Indeterminate Potential
Idiopathic Cytopenias of Undetermined Significance - Narrower
Concept UI M000676001
Preferred term Idiopathic Cytopenias of Undetermined Significance
Entry term(s) ICUS Idiopathic Cytopenias of Undetermined Significance
Clonal Cytopenia of Undetermined Significance - Narrower
Concept UI M000753236
Preferred term Clonal Cytopenia of Undetermined Significance
Entry term(s) CCUS Clonal Cytopenia of Undetermined Significance



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