| Descriptor English: | Amino Acid Chloromethyl Ketones | ||||||
| Descriptor Spanish: |
Clorometilcetonas de Aminoácidos
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| Descriptor Portuguese: | Clorometilcetonas de Aminoácidos | ||||||
| Descriptor French: | Chlorométhyl cétones d'acides aminés | ||||||
| Entry term(s): |
Chloromethyl Ketones, Peptide Ketones, Peptide Chloromethyl Peptide Chloromethyl Ketones |
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| Tree number(s): |
D12.125.065 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D000590 | ||||||
| Scope note: | Inhibitors of SERINE ENDOPEPTIDASES and sulfhydryl group-containing enzymes. They act as alkylating agents and are known to interfere in the translation process. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis EC economics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UR urine |
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| Pharm Action: |
Alkylating Agents Protein Synthesis Inhibitors Serine Proteinase Inhibitors |
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| Previous Indexing: |
Peptides (1966-1976) specific amino acid (1966-1976) |
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| Public MeSH Note: | 77; TOSYLLYSINE CHLOROMETHYL KETONE was see under LYSINE 1975-76; TOSYLPHENYLALANYL CHLOROMETHYL KETONE was see under PHENYLALANINE 1975-76 |
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| History Note: | 77 |
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| Entry Version: | AACK |
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| DeCS ID: | 594 | ||||||
| Unique ID: | D000590 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 1977/01/01 | ||||||
| Date of Entry: | 1976/05/19 | ||||||
| Revision Date: | 1999/11/09 |
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CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Amino Acid Chloromethyl Ketones
- Preferred
| Concept UI |
M0000915 |
| Scope note | Inhibitors of SERINE ENDOPEPTIDASES and sulfhydryl group-containing enzymes. They act as alkylating agents and are known to interfere in the translation process. |
| Preferred term | Amino Acid Chloromethyl Ketones |
| Entry term(s) |
Chloromethyl Ketones, Peptide Ketones, Peptide Chloromethyl Peptide Chloromethyl Ketones |
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