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Descriptor English: Tosylphenylalanyl Chloromethyl Ketone
Descriptor Spanish: Clorometilcetona de Tosilfenilalanila
Descriptor clorometilcetona de tosilfenilalanila
Entry term(s) TPCC
clorofeniltosilamidobutanona
tosilfenilalanil clorometano
Scope note: Inhibidor de las serina endopeptidasas. Actúa como agente alquilante y se sabe que interfiere en el proceso de traducción.
Descriptor Portuguese: Tosilfenilalanil Clorometil Cetona
Descriptor French: N-(1-Benzyl-3-chloroacétonyl)-para-toluènesulfonamide
Entry term(s): Chloromethane, Tosylphenylalanyl
Chloromethyl Ketone, Tosylphenylalanyl
Chlorophenyltosylamidobutanone
Ketone, Tosylphenylalanyl Chloromethyl
TPCK
Tosylphenylalanyl Chloromethane
Tree number(s): D02.065.884.060.936
D02.455.426.559.389.085.936
D02.455.426.559.389.832.710
D02.886.590.700.090.936
D02.886.590.887.660
D12.125.065.930
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D014108
Scope note: An inhibitor of Serine Endopeptidases. Acts as alkylating agent and is known to interfere with the translation process.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Alkylating Agents
Protein Synthesis Inhibitors
Serine Proteinase Inhibitors
Registry Number: 402-71-1
CAS Type 1 Name: Benzenesulfonamide, N-(3-chloro-2-oxo-1-(phenylmethyl)propyl)-4-methyl-, (S)-
Previous Indexing: Chlorine (1974)
Phenylalanine (1972-1974)
Tosyl Compounds (1973-1974)
Public MeSH Note: 91; was see under AMINO ACID CHLOROMETHYL KETONES 1977-90; was see under PHENYLALANINE 1975-76
History Note: 91(75); was see under AMINO ACID CHLOROMETHYL KETONES 1977-90; was see under PHENYLALANINE 1975-76
DeCS ID: 14500
Unique ID: D014108
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1974/11/19
Revision Date: 2000/06/22
Tosylphenylalanyl Chloromethyl Ketone - Preferred
Concept UI M0021715
Scope note An inhibitor of Serine Endopeptidases. Acts as alkylating agent and is known to interfere with the translation process.
Preferred term Tosylphenylalanyl Chloromethyl Ketone
Entry term(s) Chloromethane, Tosylphenylalanyl
Chloromethyl Ketone, Tosylphenylalanyl
Chlorophenyltosylamidobutanone
Ketone, Tosylphenylalanyl Chloromethyl
TPCK
Tosylphenylalanyl Chloromethane



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