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Descriptor English: Senescence-Associated Secretory Phenotype
Descriptor Spanish: Fenotipo Secretor Asociado a la Senescencia
Descriptor fenotipo secretor asociado a la senescencia
Entry term(s) FSAS de las células senescentes
Scope note: Fenotipo proinflamatorio paracrino desarrollado en las células senescentes. El fenotipo secretor asociado a la senescencia (FSAS) deriva del SECRETOMA inflamatorio, proteolítico y enriquecido con factores de crecimiento de muchos tipos de células senescentes, que da lugar con el tiempo a reparación de tejidos o a lesión de tejidos y órganos y que vincula el FSAS con trastornos relacionados con la edad.
Descriptor Portuguese: Fenótipo Secretor Associado à Senescência
Descriptor French: Phénotype sécrétoire associé à la sénescence
Entry term(s): Phenotype, Senescence-Associated Secretory
SASP, Senescent Cell
SASPs, Senescent Cell
Secretory Phenotype, Senescence-Associated
Senescence Associated Secretory Phenotype
Senescent Cell SASP
Senescent Cell SASPs
Tree number(s): G04.043.445
G07.345.124.130.445
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000089262
Scope note: A paracrine pro-inflammatory phenotype developed in senescing cells. The senescence-associated secretory phenotype (SASP) results from the inflammatory, proteolytic and growth factor enriched SECRETOME of many types of senescent cells which leads to tissue repair or tissue and organ damage over time and links SASP to age-related disorders.
Allowable Qualifiers: DE drug effects
GE genetics
IM immunology
PH physiology
RE radiation effects
Public MeSH Note: 2022; see CELLULAR SENESCENCE 2018-2021
History Note: 2022; use CELLULAR SENESCENCE 2018-2021
DeCS ID: 59722
Unique ID: D000089262
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2022/01/01
Date of Entry: 2021/07/09
Revision Date: 2021/07/07
Senescence-Associated Secretory Phenotype - Related but not broader or narrower
Concept UI M000630264
Scope note A paracrine pro-inflammatory phenotype developed in senescing cells. The senescence-associated secretory phenotype (SASP) results from the inflammatory, proteolytic and growth factor enriched SECRETOME of many types of senescent cells which leads to tissue repair or tissue and organ damage over time and links SASP to age-related disorders.
Preferred term Senescence-Associated Secretory Phenotype
Entry term(s) Phenotype, Senescence-Associated Secretory
SASP, Senescent Cell
SASPs, Senescent Cell
Secretory Phenotype, Senescence-Associated
Senescence Associated Secretory Phenotype
Senescent Cell SASP
Senescent Cell SASPs



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