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Descriptor English: Medium Spiny Neurons
Descriptor Spanish: Neuronas Espinosas Medianas
Descriptor neuronas espinosas medianas
Entry term(s) neuronas espinosas estriatales de tamaño mediano
Scope note: Neuronas GABAérgicas inhibidoras de tamaño mediano en el CUERPO ESTRIADO dotadas de árboles dendríticos muy desarrollados. Se dividen en neuronas que expresan RECEPTORES DE DOPAMINA D1, que se proyectan preferentemente a la PORCIÓN RETICULAR DE LA SUSTANCIA NEGRA, y neuronas que expresan RECEPTORES DE DOPAMINA D2, que se proyectan preferentemente a la parte lateral del GLOBO PÁLIDO. Las neuronas espinosas medianas se pierden de forma preferente en la ENFERMEDAD DE HUNTINGTON.
Descriptor Portuguese: Neurônios Espinhosos Médios
Descriptor French: Neurones épineux moyens
Entry term(s): Medium Spiny Neuron
Neuron, Medium Spiny
Striatal Medium Sized Spiny Neurons
Striatal Medium-Sized Spiny Neurons
Tree number(s): A08.675.289.500
A08.675.650.535
A11.671.285.500
A11.671.650.535
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000094242
Scope note: Medium sized, inhibitory GABAergic neurons in the CORPUS STRIATUM with highly developed dendritic trees. They are divided into neurons expressing DOPAMINE D1 RECEPTORS which project preferentially to the SUBSTANTIA NIGRA PARS RETICULATA and neurons expressing DOPAMINE D2 RECEPTORS which project preferentially to the lateral part of the GLOBUS PALLIDUS. Medium spiny neurons are preferentially lost in HUNTINGTON DISEASE.
Allowable Qualifiers: CH chemistry
CL classification
CY cytology
DE drug effects
EN enzymology
IM immunology
ME metabolism
MI microbiology
PA pathology
PH physiology
PS parasitology
RE radiation effects
TR transplantation
UL ultrastructure
VI virology
Previous Indexing: Corpus Striatum (1983-2022)
Neurons (1983-2022)
Public MeSH Note: 2023
History Note: 2023
Related: Corpus Striatum MeSH
DeCS ID: 60219
Unique ID: D000094242
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2023/01/01
Date of Entry: 2022/07/12
Revision Date: 2022/07/12
Medium Spiny Neurons - Preferred
Concept UI M000755725
Scope note Medium sized, inhibitory GABAergic neurons in the CORPUS STRIATUM with highly developed dendritic trees. They are divided into neurons expressing DOPAMINE D1 RECEPTORS which project preferentially to the SUBSTANTIA NIGRA PARS RETICULATA and neurons expressing DOPAMINE D2 RECEPTORS which project preferentially to the lateral part of the GLOBUS PALLIDUS. Medium spiny neurons are preferentially lost in HUNTINGTON DISEASE.
Preferred term Medium Spiny Neurons
Entry term(s) Medium Spiny Neuron
Neuron, Medium Spiny
Striatal Medium Sized Spiny Neurons
Striatal Medium-Sized Spiny Neurons



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