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Descriptor English: Proteolysis Targeting Chimera
Descriptor Spanish: Quimera Dirigida a la Proteólisis
Descriptor quimera dirigida a proteólisis
Entry term(s) PROTAC
PROTAC basadas en IAP
PROTAC basadas en VHL
PROTAC basadas en la proteína MDM2
PROTAC fosfodependientes
PROTAC, quimeras dirigidas a la proteólisis
compuestos de molécula pequeña basados en la proteína cereblon
fosfo-PROTAC
quimera dirigida a proteolisis
quimeras dirigidas a la proteólisis
Scope note: Moléculas bifuncionales diseñadas para reclutar E3 ubicuitina-ligasa para una proteína diana específica. La quimera dirigida a proteólisis consta de un ligando de proteína diana conectado a través de un conector a un ligando E3. Promueven la asociación de E3 a proteínas diana específicas marcadas para su degradación a través del proteasoma.
Descriptor Portuguese: Quimera de Direcionamento de Proteólise
Descriptor French: Chimère ciblant la protéolyse
Entry term(s): Cereblon Based Small Molecule Compounds
Cereblon-Based Small-Molecule Compounds
IAP Based PROTACs
IAP-Based PROTACs
MDM2 Protein Based PROTACs
MDM2 Protein-Based PROTACs
PROTAC Proteolysis Targeting Chimera
PROTACs
Phospho Dependent PROTACs
Phospho-Dependent PROTACs
PhosphoPROTACs
Proteolysis Targeting Chimeras
VHL Based PROTACs
VHL-Based PROTACs
Tree number(s): D27.720.470.410.210.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000094243
Scope note: Bifunctional molecules that are designed to recruit E3 UBIQUITIN LIGASE to a specific target protein. Proteolysis targeting chimera consist of a target protein ligand connected via a linker to an E3 ligand. They promote association of E3 with specific target proteins tagged for degradation via the PROTEASOME.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AN analysis
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
Previous Indexing: Proteolysis (2015-2022)
Public MeSH Note: 2023
History Note: 2023
DeCS ID: 60220
Unique ID: D000094243
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2023/01/01
Date of Entry: 2022/07/08
Revision Date: 2022/07/08
Proteolysis Targeting Chimera - Preferred
Concept UI M000755726
Scope note Bifunctional molecules that are designed to recruit E3 UBIQUITIN LIGASE to a specific target protein. Proteolysis targeting chimera consist of a target protein ligand connected via a linker to an E3 ligand. They promote association of E3 with specific target proteins tagged for degradation via the PROTEASOME.
Preferred term Proteolysis Targeting Chimera
Entry term(s) PROTAC Proteolysis Targeting Chimera
PROTACs
Proteolysis Targeting Chimeras
IAP-Based PROTACs - Narrower
Concept UI M000755731
Preferred term IAP-Based PROTACs
Entry term(s) IAP Based PROTACs
VHL-Based PROTACs - Narrower
Concept UI M000755729
Preferred term VHL-Based PROTACs
Entry term(s) VHL Based PROTACs
MDM2 Protein-Based PROTACs - Narrower
Concept UI M000755730
Preferred term MDM2 Protein-Based PROTACs
Entry term(s) MDM2 Protein Based PROTACs
Phospho-Dependent PROTACs - Narrower
Concept UI M000755727
Preferred term Phospho-Dependent PROTACs
Entry term(s) Phospho Dependent PROTACs
PhosphoPROTACs
Cereblon-Based Small-Molecule Compounds - Narrower
Concept UI M000755728
Preferred term Cereblon-Based Small-Molecule Compounds
Entry term(s) Cereblon Based Small Molecule Compounds



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