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Descriptor English: T-Cell Exhaustion
Descriptor Spanish: Agotamiento de Células T
Descriptor agotamiento de los linfocitos T
Entry term(s) agotamiento de células T
agotamiento de las células T
agotamiento de linfocitos T
Scope note: Deterioro progresivo de la función de los linfocitos T debido a la estimulación antigénica crónica y a señales inflamatorias, por ejemplo, INFECCIÓN CRÓNICA y CÁNCER. El agotamiento de los linfocitos T se caracteriza por un sistema inmunitario debilitado, por ejemplo, una diferenciación disfuncional de los LINFOCITOS T DE MEMORIA y una REPRESIÓN EPIGENÉTICA de las funciones efectoras de la MEMORIA INMUNOLÓGICA.
Descriptor Portuguese: Exaustão das Células T
Descriptor French: Épuisement des cellules T
Entry term(s): Exhaustion, T-Cell
T Cell Exhaustion
T-Lymphocyte Exhaustion
Tree number(s): G12.590.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000094383
Scope note: Progressive deterioration of T-cell function due to chronic antigen stimulation and inflammatory signals, e.g., CHRONIC INFECTION and CANCER. T-cell exhaustion is characterized by weakened immune system, e.g., dysfunctional MEMORY T CELLS differentiation and EPIGENETIC REPRESSION of IMMUNOLOGIC MEMORY effector functions.
Allowable Qualifiers: DE drug effects
GE genetics
IM immunology
PH physiology
RE radiation effects
Public MeSH Note: 2023
History Note: 2023
Related: Lymphocyte Depletion MeSH
DeCS ID: 60233
Unique ID: D000094383
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2023/01/01
Date of Entry: 2022/07/12
Revision Date: 2022/07/12
T-Cell Exhaustion - Preferred
Concept UI M000755906
Scope note Progressive deterioration of T-cell function due to chronic antigen stimulation and inflammatory signals, e.g., CHRONIC INFECTION and CANCER. T-cell exhaustion is characterized by weakened immune system, e.g., dysfunctional MEMORY T CELLS differentiation and EPIGENETIC REPRESSION of IMMUNOLOGIC MEMORY effector functions.
Preferred term T-Cell Exhaustion
Entry term(s) Exhaustion, T-Cell
T Cell Exhaustion
T-Lymphocyte Exhaustion



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