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Descriptor English: ProTides
Descriptor Spanish: ProTides
Descriptor ProTides
Entry term(s) Pro-Tide
Pro-Tides
ProTide
profármaco nucleotídico
profármacos nucleotídicos
Scope note: Grupo de profármacos constituidos por un 5'-monofosfato de nucleósido en el que los dos grupos hidroxilo están enmascarados con un éster aminoácido y un componente ariloxi que, una vez en la célula, es metabolizado enzimáticamente para liberar 5'-monofosfato libre y que posteriormente se transforma en la forma 5'-trifosfato activa del análogo nucleosídico.
Descriptor Portuguese: Ariloxifosforamidatos
Descriptor French: Without translation
Entry term(s): Nucleotide, Prodrug
Nucleotides, Prodrug
Pro Tide
Pro Tides
Pro-Tide
Pro-Tides
ProTide
Prodrug Nucleotide
Prodrug Nucleotides
Tree number(s): D13.695.623
D26.675.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000095802
Scope note: A class of prodrugs consisting of a 5'-nucleoside monophosphate in which the two hydroxyl groups are masked with an amino acid ester and an aryloxy component which once in the cell is enzymatically metabolized to deliver free 5'-monophosphate, and further transformed to the active 5'-triphosphate form of the nucleoside analogue.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Public MeSH Note: 2024
History Note: 2024
DeCS ID: 60446
Unique ID: D000095802
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2024/01/01
Date of Entry: 2023/07/26
Revision Date: 2023/06/02
ProTides - Preferred
Concept UI M000758863
Scope note A class of prodrugs consisting of a 5'-nucleoside monophosphate in which the two hydroxyl groups are masked with an amino acid ester and an aryloxy component which once in the cell is enzymatically metabolized to deliver free 5'-monophosphate, and further transformed to the active 5'-triphosphate form of the nucleoside analogue.
Preferred term ProTides
Entry term(s) Nucleotide, Prodrug
Nucleotides, Prodrug
Pro Tide
Pro Tides
Pro-Tide
Pro-Tides
ProTide
Prodrug Nucleotide
Prodrug Nucleotides



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