| Descriptor English: | ProTides | ||||||
| Descriptor Spanish: |
ProTides
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| Descriptor Portuguese: | Ariloxifosforamidatos | ||||||
| Descriptor French: | Without translation | ||||||
| Entry term(s): |
Nucleotide, Prodrug Nucleotides, Prodrug Pro Tide Pro Tides Pro-Tide Pro-Tides ProTide Prodrug Nucleotide Prodrug Nucleotides |
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| Tree number(s): |
D13.695.623 D26.675.500 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D000095802 | ||||||
| Scope note: | A class of prodrugs consisting of a 5'-nucleoside monophosphate in which the two hydroxyl groups are masked with an amino acid ester and an aryloxy component which once in the cell is enzymatically metabolized to deliver free 5'-monophosphate, and further transformed to the active 5'-triphosphate form of the nucleoside analogue. |
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| Allowable Qualifiers: |
AA analogs & derivatives AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Public MeSH Note: | 2024 |
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| History Note: | 2024 |
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| DeCS ID: | 60446 | ||||||
| Unique ID: | D000095802 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2024/01/01 | ||||||
| Date of Entry: | 2023/07/26 | ||||||
| Revision Date: | 2023/06/02 |
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CHEMICALS AND DRUGS
Pharmaceutical Preparations [D26]Pharmaceutical Preparations
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ProTides
- Preferred
| Concept UI |
M000758863 |
| Scope note | A class of prodrugs consisting of a 5'-nucleoside monophosphate in which the two hydroxyl groups are masked with an amino acid ester and an aryloxy component which once in the cell is enzymatically metabolized to deliver free 5'-monophosphate, and further transformed to the active 5'-triphosphate form of the nucleoside analogue. |
| Preferred term | ProTides |
| Entry term(s) |
Nucleotide, Prodrug Nucleotides, Prodrug Pro Tide Pro Tides Pro-Tide Pro-Tides ProTide Prodrug Nucleotide Prodrug Nucleotides |
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