| Descriptor English: | Nudix Hydrolases | ||||||
| Descriptor Spanish: |
Hidrolasas Nudix
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| Descriptor Portuguese: | Nudix Hidrolases | ||||||
| Descriptor French: | Without translation | ||||||
| Entry term(s): |
Hydrolase, Nudix Nucleoside Diphosphates Linked to Moiety X Hydrolases Nucleoside Diphosphates-Linked to Moiety-X Hydrolases Nudix Hydrolase Nudix Proteins |
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| Tree number(s): |
D08.811.277.040.600.600 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D000096964 | ||||||
| Scope note: | A group of Mg2+/Mn2+-dependent mainly pyrophosphohydrolases that hydrolyzes structures of NUcleoside DIphosphate linked to another moiety X to nucleoside monophosphate and X-Phosphate. Nudix hydrolases share conserved Nudix box (GX5EX7REUXEEXGU) and degrade variety of substrates including oxidized nucleotides (e.g., MutT) and metabolic intermediates (e.g., THIAMINE PYROPHOSPHATASE). In humans, Nudix superfamily proteins such as MutT proteins participate in DNA damage repairs. Mutations on a nudix hydrolase (NUDT15) are associated with a PURINE-PYRIMIDINE METABOLISM, INBORN ERRORS disorder called THPM2, and mutations in nudix hydrolase (NUDT2) are associated with IDDPN, a developmental intellectual disorder. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Registry Number: | EC 3.6.1.- | ||||||
| Public MeSH Note: | 2024; see under PYROPHOSPHATASES 1998-2023 |
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| History Note: | 2024 |
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| DeCS ID: | 60536 | ||||||
| Unique ID: | D000096964 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2024/01/01 | ||||||
| Date of Entry: | 2023/07/26 | ||||||
| Revision Date: | 2023/06/01 |
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CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes
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Nudix Hydrolases
- Preferred
| Concept UI |
M000762793 |
| Scope note | A group of Mg2+/Mn2+-dependent mainly pyrophosphohydrolases that hydrolyzes structures of NUcleoside DIphosphate linked to another moiety X to nucleoside monophosphate and X-Phosphate. Nudix hydrolases share conserved Nudix box (GX5EX7REUXEEXGU) and degrade variety of substrates including oxidized nucleotides (e.g., MutT) and metabolic intermediates (e.g., THIAMINE PYROPHOSPHATASE). In humans, Nudix superfamily proteins such as MutT proteins participate in DNA damage repairs. Mutations on a nudix hydrolase (NUDT15) are associated with a PURINE-PYRIMIDINE METABOLISM, INBORN ERRORS disorder called THPM2, and mutations in nudix hydrolase (NUDT2) are associated with IDDPN, a developmental intellectual disorder. |
| Preferred term | Nudix Hydrolases |
| Entry term(s) |
Hydrolase, Nudix Nucleoside Diphosphates Linked to Moiety X Hydrolases Nucleoside Diphosphates-Linked to Moiety-X Hydrolases Nudix Hydrolase Nudix Proteins |
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