PHENOMENA AND PROCESSES Chemical Phenomena [G02] Chemical Phenomena Biochemical Phenomena [G02.111] Biochemical Phenomena Molecular Structure [G02.111.570] Molecular Structure Molecular Conformation [G02.111.570.820] Molecular Conformation Protein Conformation [G02.111.570.820.709] Protein Conformation Protein Structural Elements [G02.111.570.820.709.275] Protein Structural Elements Amino Acid Motifs [G02.111.570.820.709.275.500] Amino Acid Motifs Degrons [G02.111.570.820.709.275.625] Degrons Protein Domains [G02.111.570.820.709.275.750] Protein Domains Repetitive Sequences, Amino Acid [G02.111.570.820.709.275.875] Repetitive Sequences, Amino Acid

Degrons - Preferred

Concept UI	M000764447
Scope note	Minimal elements within a protein that are sufficient for recognition and degradation by a proteolytic apparatus. Inherent degrons are comprised of short linear amino acid sequences and secondary protein structural features that increase the affinity to E3 LIGASE; and are involved in regulating the specificity and timing of PROTEIN DEGRADATION. Acquired degrons are mostly transient and conferred by post-translational modifications of specific amino acids within proteins. (From Mol Cell. 2016 Sep 15;63(6):1055-65)
Preferred term	Degrons
Entry term(s)	Degron

C-Degrons - Narrower

Concept UI	M000764681
Preferred term	C-Degrons
Entry term(s)	C Degrons C-Degron

PEST Motif - Narrower

Concept UI	M000764572
Preferred term	PEST Motif
Entry term(s)	Motif, PEST Motifs, PEST PEST Motifs PEST Sequence PEST Sequences Sequence, PEST Sequences, PEST

Destruction Box Motif - Narrower

Concept UI	M000764448
Preferred term	Destruction Box Motif
Entry term(s)	Box Motif, Destruction Box Motifs, Destruction D Box Motif D-Box Motif D-Box Motifs Destruction Box Destruction Box Motifs Destruction Boxes Motif, D-Box Motif, Destruction Box Motifs, D-Box Motifs, Destruction Box

N-Degrons - Narrower

Concept UI	M000764680
Preferred term	N-Degrons
Entry term(s)	N Degrons N-Degron