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Descriptor English: Histamine H1 Antagonists
Descriptor Spanish: Antagonistas de los Receptores Histamínicos H1
Descriptor antagonistas de los receptores histamínicos H1
Entry term(s) antagonista de los receptores histamínicos H1
antagonista histamínico H1
antagonistas de receptores de histamina H1
antagonistas del receptor H1 de la histamina
antihistaminas clásicas
antihistamínicos H1
antihistamínicos clásicos
bloqueadores de los receptores H1 de la histamina
bloqueadores de los receptores histamínicos H1
bloqueantes de receptores de histamina H1
Scope note: Fármacos que se unen selectivamente a los receptores H1 de la histamina, pero sin activarlos, bloqueando así las acciones de la histamina endógena. Entre ellos se encuentran los antihistamínicos clásicos, que antagonizan o impiden la acción de la histamina, principalmente en la hipersensibilidad inmediata. Actúan en los bronquios, los capilares y algunos otros músculos lisos, y se utilizan para prevenir o aliviar la cinetosis, la rinitis estacional y la dermatitis alérgica, así como para inducir somnolencia. No se conocen completamente los efectos del bloqueo de los receptores H1 del sistema nervioso central.
Descriptor Portuguese: Antagonistas dos Receptores Histamínicos H1
Descriptor French: Antihistaminiques des récepteurs H1
Entry term(s): Antagonists, Histamine H1
Antagonists, Histamine H1 Receptor
Antihistamines, Classical
Antihistamines, Sedating
Antihistaminics, Classical
Antihistaminics, H1
Blockaders, Histamine H1 Receptor
Classical Antihistamines
Classical Antihistaminics
First Generation H1 Antagonists
H1 Antagonists, Histamine
H1 Antihistaminics
H1 Receptor Blockaders
Histamine H1 Antagonist
Histamine H1 Blockers
Histamine H1 Receptor Antagonist
Histamine H1 Receptor Antagonists
Histamine H1 Receptor Blockaders
Receptor Blockaders, H1
Sedating Antihistamines
Tree number(s): D27.505.519.625.375.425.400
D27.505.696.577.375.425.400
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D006634
Scope note: Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood.
Annotation: HISTAMINE H1 ANTAGONISTS, NON-SEDATING is also available
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Public MeSH Note: 95; was HISTAMINE H1 RECEPTOR BLOCKADERS 1977-94; was ANTIHISTAMINICS 1963-76; ANTIHISTAMINICS, CLASSICAL was ANTIHISTAMINICS see HISTAMINE H1 RECEPTOR BLOCKADERS 1977-90
Online Note: use HISTAMINE H1 ANTAGONISTS to search HISTAMINE H1 RECEPTOR BLOCKADERS 1977-94 and ANTIHISTAMINICS 1966-76
History Note: 95; was HISTAMINE H1 RECEPTOR BLOCKADERS 1977-94; was ANTIHISTAMINICS 1963-76; ANTIHISTAMINICS, CLASSICAL was ANTIHISTAMINICS see HISTAMINE H1 RECEPTOR BLOCKADERS 1977-90
Entry Version: HISTAMINE H1 ANTAG
Related: Anti-Allergic Agents MeSH
Bronchodilator Agents MeSH
Hypersensitivity, Immediate MeSH
DeCS ID: 6793
Unique ID: D006634
NLM Classification: QV 157
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1977/01/01
Date of Entry: 1976/05/05
Revision Date: 2008/07/08
Histamine H1 Antagonists - Preferred
Concept UI M0010395
Scope note Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood.
Preferred term Histamine H1 Antagonists
Entry term(s) Antagonists, Histamine H1
Antagonists, Histamine H1 Receptor
Antihistaminics, H1
Blockaders, Histamine H1 Receptor
H1 Antagonists, Histamine
H1 Antihistaminics
H1 Receptor Blockaders
Histamine H1 Antagonist
Histamine H1 Blockers
Histamine H1 Receptor Antagonist
Histamine H1 Receptor Antagonists
Histamine H1 Receptor Blockaders
Receptor Blockaders, H1
Antihistamines, Classical - Narrower
Concept UI M0503956
Preferred term Antihistamines, Classical
Entry term(s) Antihistamines, Sedating
Antihistaminics, Classical
Classical Antihistamines
Classical Antihistaminics
First Generation H1 Antagonists
Sedating Antihistamines



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