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Descriptor English: 4-Hydroxycoumarins
Descriptor Spanish: 4-Hidroxicumarinas
Descriptor 4-hidroxicumarinas
Scope note: Sustancias presentes en muchas plantas, que contienen el radical 4-hidroxicumarina. Interfieren con la vitamina K y el mecanismo de coagulación de la sangre, se unen fácilmente a proteínas, inhiben enzimas microsomales y mitocondriales, y se utilizan como anticoagulantes orales.
Descriptor Portuguese: 4-Hidroxicumarinas
Descriptor French: 4-Hydroxycoumarines
Entry term(s): 4 Hydroxycoumarins
Tree number(s): D03.383.663.283.446.520
D03.633.100.150.446.520
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D015110
Scope note: Substances found in many plants, containing the 4-hydroxycoumarin radical. They interfere with vitamin K and the blood clotting mechanism, are tightly protein-bound, inhibit mitochondrial and microsomal enzymes, and are used as oral anticoagulants.
Annotation: /biosyn permitted if by plant
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Anticoagulants
Enzyme Inhibitors
Previous Indexing: Coumarins (1972-1976)
Public MeSH Note: 77; PHENPROCOUMON was see under COUMARINS 1975-76
History Note: 77
DeCS ID: 7056
Unique ID: D015110
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1977/01/01
Date of Entry: 1976/04/13
Revision Date: 2016/05/27
4-Hydroxycoumarins - Preferred
Concept UI M0023241
Scope note Substances found in many plants, containing the 4-hydroxycoumarin radical. They interfere with vitamin K and the blood clotting mechanism, are tightly protein-bound, inhibit mitochondrial and microsomal enzymes, and are used as oral anticoagulants.
Preferred term 4-Hydroxycoumarins
Entry term(s) 4 Hydroxycoumarins



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