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Descriptor English: Hypoglycins
Descriptor Spanish: Hipoglicinas
Descriptor hipoglicinas
Scope note: Metileno ciclopropil alanina y congéneres aislados de la fruta inmadura comestible de la planta AKEE (BLIGHIA SAPIDA). La hipoglicina B es el congénere gamma-glutamil de la hipoglicina A. Son muy tóxicos y teratógenos, causando un síndrome denominado enfermedad de los vómitos de Jamaica que incluye una caída en la glucemia debido a una interferencia de los ÁCIDOS GRASOS y del metabolismo de la LEUCINA que lleva a VÓMITOS, daño hepático, CONVULSIONES y MUERTE.
Descriptor Portuguese: Hipoglicinas
Descriptor French: Hypoglycines
Tree number(s): D02.455.426.392.368.533.450
D23.946.412
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D007005
Scope note: Methylene cyclopropyl alanine and congeners isolated from the unripe edible fruit of the AKEE plant (BLIGHIA SAPIDA). Hypoglycin B is the gamma-glutamyl congener of hypoglycin A. They are very toxic and teratogenic, causing a syndrome called Jamaican vomiting sickness that includes a fall in blood glucose due to the interference of FATTY ACIDS and LEUCINE metabolism which leads to VOMITING, liver damage, CONVULSIONS and DEATH.
Annotation: Jamaican vomiting sickness : coordinate HYPOGLYCINS /pois (IM) with PLANT POISONING (IM)
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Poisons
Previous Indexing: Alanine (1973-1976)
Cyclopropanes (1970-1976)
Public MeSH Note: 91; was see under CYCLOPROPANES 1977-90
History Note: 91(77); was see under CYCLOPROPANES 1977-90
DeCS ID: 7183
Unique ID: D007005
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1976/04/16
Revision Date: 2005/06/30
Hypoglycins - Preferred
Concept UI M0010904
Scope note Methylene cyclopropyl alanine and congeners isolated from the unripe edible fruit of the AKEE plant (BLIGHIA SAPIDA). Hypoglycin B is the gamma-glutamyl congener of hypoglycin A. They are very toxic and teratogenic, causing a syndrome called Jamaican vomiting sickness that includes a fall in blood glucose due to the interference of FATTY ACIDS and LEUCINE metabolism which leads to VOMITING, liver damage, CONVULSIONS and DEATH.
Preferred term Hypoglycins



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