Descriptor in English: | Picrotoxin |
Descriptor in Spanish: | Picrotoxina |
Descriptor in Portuguese: | Picrotoxina |
Descriptor in French: | Picrotoxine |
Tree number(s): |
D02.455.426.392.368.367.800 D02.540.552 |
Scope note: | A noncompetitive antagonist at GABA-A receptors and thus a convulsant. Picrotoxin blocks the GAMMA-AMINOBUTYRIC ACID-activated chloride ionophore. Although it is most often used as a research tool, it has been used as a CNS stimulant and an antidote in poisoning by CNS depressants, especially the barbiturates. |
Allowable Qualifiers: |
AA analogs & derivatives AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis EC economics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UR urine |
DeCS UI: | 11284 |
Descriptor UI: | D010852 |
Date Established: | 1966/01/01 |
Date of Entry: | 1999/01/01 |
Revision Date: | 2006/07/05 |
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CHEMICALS AND DRUGS
Organic Chemicals [D02]Organic Chemicals -
CHEMICALS AND DRUGS
Organic Chemicals [D02]Organic Chemicals
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Picrotoxin
- Preferred
Concept UI |
M0016843 |
Scope note | A noncompetitive antagonist at GABA-A receptors and thus a convulsant. Picrotoxin blocks the GAMMA-AMINOBUTYRIC ACID-activated chloride ionophore. Although it is most often used as a research tool, it has been used as a CNS stimulant and an antidote in poisoning by CNS depressants, especially the barbiturates. |
Preferred term | Picrotoxin |
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