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Descriptor English: Picrotoxin
Descriptor Spanish: Picrotoxina
Descriptor picrotoxina
Scope note: Antagonista no competitivo de los receptores GABA-A y, por tanto, convulsionante. La picrotoxina bloquea el complejo ionóforo de cloruro activado por el ÁCIDO GAMMA-AMINOBUTÍRICO. Aunque se utiliza más comunmente como herramienta de investigación, se ha utilizado también como estimulante del SNC y como antídoto en intoxicaciones causadas por depresores del SNC, especialmente barbitúricos.
Descriptor Portuguese: Picrotoxina
Descriptor French: Picrotoxine
Tree number(s): D02.455.426.392.368.367.800
D02.540.552
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D010852
Scope note: A noncompetitive antagonist at GABA-A receptors and thus a convulsant. Picrotoxin blocks the GAMMA-AMINOBUTYRIC ACID-activated chloride ionophore. Although it is most often used as a research tool, it has been used as a CNS stimulant and an antidote in poisoning by CNS depressants, especially the barbiturates.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Central Nervous System Stimulants
Antidotes
Convulsants
GABA Antagonists
Registry Number: 124-87-8
CAS Type 1 Name: 3,6-Methano-8H-1,5,7-trioxacyclopenta(ij)cycloprop(a)azulene-4,8(3H)-dione, hexahydro-2a-hydroxy-9-(1-hydroxy-1-methylethyl)-8b-methyl-, (1aR-(1aalpha,2abeta,3beta,6beta,6abeta,8aS*,8bbeta,9S*))-, compd. with (1aR-(1aalpha,2abeta,3beta,6beta,6abeta,8aS*,8bbeta,9R*))-hexahydro-2a-hydroxy-8b-methyl-9-(1-methylethenyl)-3,6-methano-8H-1,5,7-trioxacyclopenta(ij)cycloprop(a)azulene-4,8(3H)-dione (1:1)
DeCS ID: 11284
Unique ID: D010852
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1966/01/01
Date of Entry: 1999/01/01
Revision Date: 2006/07/05
Picrotoxin - Preferred
Concept UI M0016843
Scope note A noncompetitive antagonist at GABA-A receptors and thus a convulsant. Picrotoxin blocks the GAMMA-AMINOBUTYRIC ACID-activated chloride ionophore. Although it is most often used as a research tool, it has been used as a CNS stimulant and an antidote in poisoning by CNS depressants, especially the barbiturates.
Preferred term Picrotoxin



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