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Descriptor in English: Picrotoxin
Descriptor in Spanish: Picrotoxina
Descriptor in Portuguese: Picrotoxina
Descriptor in French: Picrotoxine
Tree number(s): D02.455.426.392.368.367.800
D02.540.552
Scope note: A noncompetitive antagonist at GABA-A receptors and thus a convulsant. Picrotoxin blocks the GAMMA-AMINOBUTYRIC ACID-activated chloride ionophore. Although it is most often used as a research tool, it has been used as a CNS stimulant and an antidote in poisoning by CNS depressants, especially the barbiturates.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
DeCS UI: 11284
Descriptor UI: D010852
Date Established: 1966/01/01
Date of Entry: 1999/01/01
Revision Date: 2006/07/05
Picrotoxin - Preferred
Concept UI M0016843
Scope note A noncompetitive antagonist at GABA-A receptors and thus a convulsant. Picrotoxin blocks the GAMMA-AMINOBUTYRIC ACID-activated chloride ionophore. Although it is most often used as a research tool, it has been used as a CNS stimulant and an antidote in poisoning by CNS depressants, especially the barbiturates.
Preferred term Picrotoxin



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