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Descriptor English: Iduronidase
Descriptor Spanish: Iduronidasa
Descriptor iduronidasa
Scope note: Enzima que hidroliza enlaces iduronosídicos en el dermatán desulfatado. La deficiencia de esta enzima produce el síndrome de Hurler. EC 3.2.1.76.
Descriptor Portuguese: Iduronidase
Descriptor French: L-iduronidase
Entry term(s): alpha L Idosiduronase
alpha L Iduronidase
alpha-L-Idosiduronase
alpha-L-Iduronidase
Tree number(s): D08.811.277.450.560
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D007068
Scope note: An enzyme that hydrolyzes iduronosidic linkages in desulfated dermatan. Deficiency of this enzyme produces Hurler's syndrome. EC 3.2.1.76.
Annotation: /defic: consider also MUCOPOLYSACCHARIDOSIS I
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 3.2.1.76
CAS Type 1 Name: Glycosaminoglycan alpha-L-iduronohydrolase
Previous Indexing: Glycoside Hydrolases (1972-1974)
Hexoses (1972-1974)
Uronic Acids (1972-1974)
Public MeSH Note: 91; was see under GLYCOSIDE HYDROLASES 1975-90
History Note: 91(75); was see under GLYCOSIDE HYDROLASES 1975-90
Related: Mucopolysaccharidosis I MeSH
DeCS ID: 7251
Unique ID: D007068
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1974/11/19
Revision Date: 2003/07/09
Iduronidase - Preferred
Concept UI M0010998
Scope note An enzyme that hydrolyzes iduronosidic linkages in desulfated dermatan. Deficiency of this enzyme produces Hurler's syndrome. EC 3.2.1.76.
Preferred term Iduronidase
Entry term(s) alpha L Idosiduronase
alpha L Iduronidase
alpha-L-Idosiduronase
alpha-L-Iduronidase



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