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Descriptor English: Insulin, Isophane
Descriptor Spanish: Insulina Isófana
Descriptor insulina isófana
Entry term(s) insulina NPH
Scope note: Forma modificada de insulina que contiene protamina y zinc. La insulina isófana es una INSULINA de acción intermedia cuya acción comienza aproximadamente 2 horas después de la administración y se prolonga durante 24 horas.
Descriptor Portuguese: Insulina Isófana
Descriptor French: Insuline isophane
Entry term(s): Hagedorn Insulin, Protamine
Insulin, NPH
Insulin, Protamine Zinc
Isophane Insulin
Isophane Insulin, Regular
NPH Insulin
Neutral Protamine Hagedorn Insulin
Protamine Hagedorn Insulin
Protamine Zinc Insulin
Regular Isophane Insulin
Zinc Insulin, Protamine
Tree number(s): D06.472.699.587.200.300.200
D12.644.548.586.200.300.200
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D007336
Scope note: An intermediate-acting INSULIN preparation with onset time of 2 hours and duration of 24 hours. It is produced by crystallizing ZINC-insulin-PROTAMINES at neutral pH 7. Thus it is called neutral protamine Hagedorn for inventor Hans Christian Hagedorn.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Entry Combination: antagonists & inhibitors:Insulin Antagonists
Pharm Action: Hypoglycemic Agents
Registry Number: 53027-39-7
CAS Type 1 Name: Insulin Isophane
Public MeSH Note: 2009; see INSULIN, NPH 2009-2011; see INSULIN, ISOPHANE 1963-2008; for INSULIN, PROTAMINE ZINC see INSULIN, LONG-ACTING 1966-2011
History Note: 2009 (1963); for INSULIN, PROTAMINE ZINC use INSULIN, LONG-ACTING 1966-2011
DeCS ID: 7505
Unique ID: D007336
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2009/01/01
Date of Entry: 1999/01/01
Revision Date: 2015/05/26
Insulin, Isophane - Preferred
Concept UI M0011436
Scope note An intermediate-acting INSULIN preparation with onset time of 2 hours and duration of 24 hours. It is produced by crystallizing ZINC-insulin-PROTAMINES at neutral pH 7. Thus it is called neutral protamine Hagedorn for inventor Hans Christian Hagedorn.
Preferred term Insulin, Isophane
Entry term(s) Hagedorn Insulin, Protamine
Insulin, NPH
Isophane Insulin
Isophane Insulin, Regular
NPH Insulin
Neutral Protamine Hagedorn Insulin
Protamine Hagedorn Insulin
Regular Isophane Insulin
Insulin, Protamine Zinc - Related but not broader or narrower
Concept UI M0011440
Preferred term Insulin, Protamine Zinc
Entry term(s) Protamine Zinc Insulin
Zinc Insulin, Protamine



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